SERUM SIALIC ACID LEVEL IN DIABETIC RETINOPATHY

Authors

  • M. Zamir Ahmad Akbri
  • Abdus Salam Sheikh
  • Muhammad Sarwar Bhatti
  • Muhammad Hussnain
  • Zafar Ali Chaudhry

Abstract

Background: The purpose of the study was to investigate the previously reported observations that patients with
elevated levels of serum sialic acid are more prone to develop retinopathy. Methods: Fasting blood glucose and serum
sialic acid levels were estimated in sixty diabetic patients with and without retinopathy between 30-60 years of age.
Thirty normal persons of same age group were included as controls. Fundoscopy was done to confirm retinopathy.
Serum sialic acid concentration was elevated in diabetic patients both with and without retinopathy but the increase
was much significant in patients with diabetic retinopathy. Results: A significant correlation of serum sialic acid level
with duration of diabetes and degree of retinal involvement was noticed in this study

References

Tattersall R-B. Diabetes in elderly a neglected area?

Diabetologia 1984:27: 167-73

American Academy of Ophthalmology Quality Care

Committee. (1993) Preferred practice pattern for diabetic

retinopathy. American Academy of Ophthalmology, 665

Beach St San Francisco, CA 9424.

Engerman R. Relationship of microvascular disease in

diabetes to metabolic control. Diabetes, 1977: 26: 760-69.

Kohner E.M. Diabetic eye disease in complications of

diabetes: Edward Arnol London 1982; 19-108, as quoted in W

H O. Technical report series, 1985.

Ciaraldi TP. Neuraminidase treatment of isolated rat

adipocytes and differential regulation of basal and insulin

stimulated glucose transport Diabetes 1989:38 951-58.

Stryer L. Biochemistry 2nd Eds. W.H. Freeman New

York,1981 ;462-63.

Crook M The determination of plasma or serum Sialic Acid

Clin Biochem. 1993:26:31-38

Alvi M H, Shaikh S.A. Serum sialic acid as tumour marker and

the effect of therapy in cancer patients. Proceedings

SZPGMI,1992;6:11-19

Hayes B.K and Varki A.O. Acetylation and di-o-acetylation of

sialic acid. J. Biol. Chem. 1989; 264(32): 19443-7

Bergmeyer H.U, Bergmeyer J, Grable H Methods of

enzymatic analysis, 3rd Eds, Vol-1. Florida, Value Chem.

:80-90

Alvi M.H, Amer N, Sumrin I. Serum 5-Nucleotidasc and

serum sialic acid in pregnancy. Obstet. Gynaecol 1988 72:171-

Plucinsky M.C, Rily W.M, Prorok J.J. and Alhadett J A. Total

and lipid associated serum sialic acid levels in cancer patients

with different primary sites and differing degrees of metastatic

involvement. Cancer 1986; 58:2680-85.

Ekhe G I and Ibeh G O Sialic acid in Sickle cell disease. Clin.

Chem. 1988,34:1443-46.

Syrbe G, Schroder H, Keil E. and Jutte A. Multivariate

analysis for understanding typical diabetic homeostasis,

criteria and determination of typical retinopathy parameter.

Folia Haematol. Int Mag Klin Morphol Blutfprsch

,117(5). 731-37.

Rehman and Rehman a Studies on glycosylated plasma

proteins in diabetes mellitus. JPMA.1991; 41(17): 16-18.

Jons A and Wales J K Blood glycoprotein j levels in diabetes

mellitus. Diabetologia, I976; l2:245

Korte G E. Labelling of regenerating retinal pigment

epithelium by colloidal iron oxide and ferritin. Cell tissue

research 1991,264(1): 103-110.

Rehman M.A, Zafar G, and Shera AS. Changes glycosylated

protons in long diabetes mellitus. Biomed Pharmcother

I990.44(4).229-34

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How to Cite

Akbri, M. Z. A., Sheikh, A. S., Bhatti, M. S., Hussnain, M., & Chaudhry, Z. A. (2001). SERUM SIALIC ACID LEVEL IN DIABETIC RETINOPATHY. Journal of Ayub Medical College Abbottabad, 13(1), 29–30. Retrieved from https://demo.ayubmed.edu.pk/jamc/index.php/jamc/article/view/4841

Issue

Vol. 13 No. 1 (2001): JOURNAL OF AYUB MEDICAL COLLEGE, ABBOTTABAD

Section

ORIGINAL ARTICLE

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