LIPID PROFILE IN OBESITY
Abstract
Background: Obesity is associated with social and medical risks that especially make it a problem. The importanceof obesity in the prediction of cardiovascular disease has been the subject of long standing debate. Direct correlationbetween plasma triglycerides and body weight have been noticed. We report the results of a study in our center.Methods: Fifty adult subjects who were obese (body mass index > 25 Kg/m) and nonsmokers were selected alongwith thirty non obese nonsmokers as controls. Lipid profile was studied including total lipids, total cholesterol. HDL,LDL, VLDL and chylomicrons. Various ratios like LDL/HDL, VLDL/HDL, TG/HDL and TC/HDL ratios werecalculated to find the risk of atherosclerosis and coronary heart disease. Results: All the parameters except serumHDL. level showed significant increase in obese persons while HDL level was significantly decreased.References
Kannel, W.B. Metabolic risk factor for coronan heart
disease in women. AM. Heart. J. 1987 114: 4 i j-19
Garrison. R J. Castelli W P. Obesity and Lipoprotein
Cholesterol in the Farm Ingham off spring study
Metabolism 1986:29; 1053.
Garrow J.S.S (1981). Treat obesity seriously.
Edinburgh: Churchill Livingstone. Quetlel LA.
Physique, Social. Brussels Marquardt 1969
Truswell A S. (1985) Obesity, diagnosis and risk in
British.Med.J.1985: 291:655-57.
Gam, S.M & Hawthorne V.M. Fatness and mortality in
the west of Scotland. Am. J Clin Nutr 1983:38 313-19.
Lorett P & Askevold E.M. The Oslo Study,
Cardiovascular disease in middle aged and young Oslo
men Acta Med. Scand. Suppl 1977: 588
Garden. T. Castelli. W. P Diabetes, blood lipids and the
role of obesity in coronary heart disease r.sk for women
The Framingham Study. Ann Intern. Med.
1977:83' 393-397.
Sonja L.C & William E The effect of age, body weight
and family relationship on plasma lipoproteins
Circulation. 1982:65:1290-97.
Morrison J.A & Laskarzevyiski. Intra-familial
Associations of Lipids and Lipoproteins in kindred with
hyper triglycerdemic probands Circulation 1982 66:67
Robertson T. Kato H. & Garden T Epidemiological
studies of coronary hear! disease & strokes in Japanese
men living in Hawaii and California. Am..1. Cardiol.
: 39:239-43.
Garden, T. Castelli, W.P. Kannel W B. High density
lipoproteins as a protective factor against coronary
heart disease AM. J. Med 1977: 62: 707.
Varley H. Govenlock H. A & Bell M (1984) Practical
Clinical Biochemistry Vol. l. William Heinemann
Medical Books Ltd. London, p 677
Hojnack. J., Mulligan, J. & Cluette-Brown, J. Oral
nicotine impairs clearance of plasma Low Density
Lipoproteins. Proc Soc. Exp. Biol. Med. 1986:
:444-18.
Rabkin S W & Mathewson F A. Relationship of body
weight to development of ischaemic heart disease in a
cohort of young North American Men. Manitoba Study.
Amer.LCardiol.1977: 39:452.
Sorenson T. & Sonne H.S.M. Mortality in extremely
young overweight men. J.Chronic.Dis.1977: 30: 359-
Friedman. C.L & Falko, J.M.: Serum Lipoprotein
responses during active & Stable weight reduction in
reproductive obese females. 1982
Kesaneimi. Y.A and Grundy. Significance of low
density lipoprotein production in the regulation of
plasma cholesterol level in men. J. Clin. Invest. 1982:
Vol. 70 13-22.
Cluette-Brown, J. & Hogan. S. Oral nicotine induces an
atherogenic lipoprotein profile. Proc. Soc Exp. Bio
Med 1986: 182:409-13.
National Cholesterol Education Programme Expert
Panel. Detection, evaluation and treatment of high
blood cholesterol in adults. Arch. Intern. Med. 1988:
:36-39.
Stein E.A. Management of hypercholesterolemia.
Approach to diet and drug therapy. Am. J. Med.
:87:20-27.
Castelli, W.P. Rober, D & McNamara, A.B.: Summary
estimates of cholesterol used to predict coronary heart
disease. Circulation 1983. 687m 730-34.
Guyton. C. Female Physiology before pregnancy 8th
Eds. W.B. Saunder's Company Philadelphia 1991. pp
Razay G., Heaton K.W and Bolton C H. Coronary
Heart Disease risk factors in relation to menopause.
Quarterly J. Med. 1992: 889-96.
Framingham Study. William P. Castelli The
triglyceride issue: A view from Framingham. Am.
Heart J August, 1986: 432-437.
Kannel, W.B. & Castelli W.P. Cholesterol in the
prediction of atherosclerotic disease. Framingham
Study. Ann. Intern. Med. 1979:90: 85.
Castelli WP. Cardiovascular disease in women. AN. J
Obstet. Gynaecol. 1988: 1046-1060.
Downloads
Issue
Section
License
Journal of Ayub Medical College, Abbottabad is an OPEN ACCESS JOURNAL which means that all content is FREELY available without charge to all users whether registered with the journal or not. The work published by J Ayub Med Coll Abbottabad is licensed and distributed under the creative commons License CC BY ND Attribution-NoDerivs. Material printed in this journal is OPEN to access, and are FREE for use in academic and research work with proper citation. J Ayub Med Coll Abbottabad accepts only original material for publication with the understanding that except for abstracts, no part of the data has been published or will be submitted for publication elsewhere before appearing in J Ayub Med Coll Abbottabad. The Editorial Board of J Ayub Med Coll Abbottabad makes every effort to ensure the accuracy and authenticity of material printed in J Ayub Med Coll Abbottabad. However, conclusions and statements expressed are views of the authors and do not reflect the opinion/policy of J Ayub Med Coll Abbottabad or the Editorial Board.
USERS are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author. This is in accordance with the BOAI definition of open access.
AUTHORS retain the rights of free downloading/unlimited e-print of full text and sharing/disseminating the article without any restriction, by any means including twitter, scholarly collaboration networks such as ResearchGate, Academia.eu, and social media sites such as Twitter, LinkedIn, Google Scholar and any other professional or academic networking site.
