OUTCOME OF RECURRENT MACULAR HOLE CLOSURE WITH AMNIOTIC MEMBRANE PLUG

Authors

  • Syed Muhammad Saad Department of Ophthalmology, Layton Rehmatullah Benevolent Trust free tertiary Care Eye Hospital, Karachi-Pakistan
  • Syed Fawad Rizvi Ophthalmology Department, Layton Rahmatullah Benevolent Trust Free Eye Hospital, Korangi, Karachi, Sindh
  • Muhammad Abdullah Tufail Khan Ophthalmology Department, Layton Rahmatullah Benevolent Trust Free Eye Hospital, Korangi, Karachi, Sindh
  • Syed Asaad Mahmood Ophthalmology Department, Layton Rahmatullah Benevolent Trust Free Eye Hospital, Korangi, Karachi, Sindh
  • Sabeen Abbasi Ophthalmology Department, Layton Rahmatullah Benevolent Trust Free Eye Hospital, Korangi, Karachi, Sindh
  • M. Tanweer Hasan Khan Ophthalmology Department, Layton Rahmatullah Benevolent Trust Free Eye Hospital, Korangi, Karachi, Sindh

Abstract

Background: The surgery of macular hole is a complex and intricate micro-surgery and chances of recurrence of macular hole are always high. Therefore, in order to provide a medium to close this hole, we carried out this research on subjects using amniotic membrane, in light of the studies being conducted around the world. This in turn led to benefitting the patients by improving their vision over time. Purpose: To assess the rate of recurrent macular hole closure with amniotic membrane plug. It was a Quasi-experimental study, conducted at Layton Rahmatullah Benevolent Trust (LRBT) Free Eye Hospital Karachi, from January 2019 to January 2020. Methods: This study was conducted using 13 eyes of 13 patients with recurrent macular hole who underwent amniotic membrane plugging via pars plana approach. Outcomes measured were changes in best corrected visual acuity (BCVA) and change in hole size with the help of optical coherence tomography (OCT). Results: Anatomic closure was attained in 100% of the cases whereas BCVA improved from 1.7±0.33 (6/300) to 0.9±0.15 (6/48). Conclusion: The use of AM is a functional method for management of large RMH.

Author Biography

Syed Muhammad Saad, Department of Ophthalmology, Layton Rehmatullah Benevolent Trust free tertiary Care Eye Hospital, Karachi-Pakistan

Department of vitreoretina

Ophthalmogist

References

Salmon J. Kanski's Clinical Ophthalmology E-Book: A Systematic Approach: Elsevier Health Sciences, 2019; p.596-7.

Kang SW, Ahn K, Ham DI. Types of macular hole closure and their clinical implications. Br J Ophthalmol 2003;87(8):1015-9.

D'Souza MJ, Chaudhary V, Devenyi R, Kertes PJ, Lam WC. Re-operation of idiopathic full-thickness macular holes after initial surgery with internal limiting membrane peel. Br J Ophthalmol 2011;95(11):1564-7.

Singh S. Repeat gas insufflation for successful closure of idiopathic macular hole following failed primary surgery--our experience. Indian J Ophthalmol 2014;62(12):1177.

van Herendael BJ, Oberti C, Brosens I. Microanatomy of the human amniotic membranes. A light microscopic, transmission, and scanning electron microscopic study. Am J Obstet Gynecol 1978;131(8):872-80.

Prabhasawat P, Tesavibul N. Preserved Amniotic Membrane Transplantation for Conjunctival Surface Reconstruction. Cell Tissue Bank 2001;2(1):31-9.

Caporossi T, De Angelis L, Pacini B, Tartaro R, Finocchio L, Barca F, et al. A human Amniotic Membrane plug to manage high myopic macular hole associated with retinal detachment. Acta Ophthalmol 2020;98(2):e252-6.

Kiilgaard JF, Scherfig E, Prause JU, la Cour M. Transplantation of Amniotic Membrane to the Subretinal Space in Pigs. Stem Cells Int 2012;2012:716968.

Rizzo S, Caporossi T, Tartaro R, Finocchio L, Franco F, Barca F, et al. A Human Amniotic Membrane Plug to Promote Retinal Breaks Repair and Recurrent Macular Hole Closure. Retina 2019;39(Suppl 1):S95-103.

Chen SN, Yang CM. Lens capsular flap transplantation in the management of refractory macular hole from multiple etiologies. Retina 2016;36(1):163-70.

Peng J, Chen C, Jin H, Zhang H, Zhao P. Autologous lens capsular flap transplantation combined with autologous blood application in the management of refractory macular hole. Retina 2018;38(11):2177-83.

Lai CC, Chen YP, Wang NK, Chuang LH, Liu L, Chen KJ, et al. Vitrectomy with Internal Limiting Membrane Repositioning and Autologous Blood for Macular Hole Retinal Detachment in Highly Myopic Eyes. Ophthalmology 2015;122(9):1889-98.

Morizane Y, Shiraga F, Kimura S, Hosokawa M, Shiode Y, Kawata T, et al. Autologous transplantation of the internal limiting membrane for refractory macular holes. Am J Ophthalmol 2014;157(4):861-9.e1.

Dai Y, Dong F, Zhang X, Yang Z. Internal limiting membrane transplantation for unclosed and large macular holes. Graefes Arch Clin Exp Ophthalmol 2016;254(11):2095-9.

Grewal DS, Mahmoud TH. Autologous Neurosensory Retinal Free Flap for Closure of Refractory Myopic Macular Holes. JAMA Ophthalmol 2016;134(2):229-30.

Wu AL, Chuang LH, Wang NK, Chen KJ, Liu L, Yeung L, et al. Refractory macular hole repaired by autologous retinal graft and blood clot. BMC Ophthalmol 2018;18(1):213.

Grewal DS, Charles S, Parolini B, Kadonosono K, Mahmoud TH. Autologous Retinal Transplant for Refractory Macular Holes: Multicenter International Collaborative Study Group. Ophthalmology 2019;126(10):1399-408.

Lee SM, Kwon HJ, Park SW, Lee JE, Byon IS. Microstructural changes in the fovea following autologous internal limiting membrane transplantation surgery for large macular holes. Acta Ophthalmol 2018;96(3):e406-8.

Bhatnagar P, Kaiser PK, Smith SD, Meisler DM, Lewis H, Sears JE. Reopening of previously closed macular holes after cataract extraction. Am J Ophthalmol 2007;144(2):252-9.

Abbey AM, Van Laere L, Shah AR, Hassan TS. Recurrent macular holes in the era of small-gauge vitrectomy: A Review of Incidence, Risk Factors, and Outcomes. Retina 2017;37(5):921-4.

Downloads

Published

2021-04-23

How to Cite

Saad, S. M., Syed Fawad Rizvi, Muhammad Abdullah Tufail Khan, Syed Asaad Mahmood, Sabeen Abbasi, & M. Tanweer Hasan Khan. (2021). OUTCOME OF RECURRENT MACULAR HOLE CLOSURE WITH AMNIOTIC MEMBRANE PLUG. Journal of Ayub Medical College Abbottabad, 33(2), 179–182. Retrieved from https://demo.ayubmed.edu.pk/jamc/index.php/jamc/article/view/9002

Issue

Vol. 33 No. 2 (2021): Journal of Ayub Medical College Abbottabad

Section

ORIGINAL ARTICLE

License

Journal of Ayub Medical College, Abbottabad is an OPEN ACCESS JOURNAL which means that all content is FREELY available without charge to all users whether registered with the journal or not. The work published by J Ayub Med Coll Abbottabad is licensed and distributed under the creative commons License  CC BY ND Attribution-NoDerivs. Material printed in this journal is OPEN to access, and are FREE for use in academic and research work with proper citation. J Ayub Med Coll Abbottabad accepts only original material for publication with the understanding that except for abstracts, no part of the data has been published or will be submitted for publication elsewhere before appearing in J Ayub Med Coll Abbottabad. The Editorial Board of J Ayub Med Coll Abbottabad makes every effort to ensure the accuracy and authenticity of material printed in J Ayub Med Coll Abbottabad. However, conclusions and statements expressed are views of the authors and do not reflect the opinion/policy of J Ayub Med Coll Abbottabad or the Editorial Board.

USERS are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author. This is in accordance with the BOAI definition of open access.

AUTHORS retain the rights of free downloading/unlimited e-print of full text and sharing/disseminating the article without any restriction, by any means including twitter, scholarly collaboration networks such as ResearchGate, Academia.eu, and social media sites such as Twitter, LinkedIn, Google Scholar and any other professional or academic networking site.