A STUDY OF SERUM LIPID PATTERN IN THALASSAEMIC PATIENTS

Authors

  • Muhammad Tayyab
  • Muhammad Abdullah
  • Allah Ditta

Abstract

Background: Thalassaemia is among the most common genetic diseases of man and the commonest inherited disorder
in our country. This study was carried out to assess the lipid pattern in thalassaemic patients and to find out any
significant variation in lipid pattern of these patients. Methods: Eighty thalassaemic patients (Group A) were selected
from various blood transfusion centers and hospitals. Fifty, age and sex matched, normal controls (Group B) were also
included in the study. 3.0 ml blood was drawn aseptically from the antecubital vein of each subject. The serum was
separated and stored at 4°C till analysed. Serum total cholesterol (TC) and triglycerides (TG) of all the subjects were
estimated using the commercially available kits. Results: There was a statistically significant difference (P<0.05) in
the serum TC concentrations of thalassaemic patients as compared to those of normal controls. Scrum TG levels of
thalassaemic patients were raised as compared to those of normal controls (though not statistically significant).
Conclusion: There is a need to design a larger study to evaluate the real status of lipids and lipoprotein subtractions in
thalassaemic patients.

References

Nienhuis AW. Anagnou XP, Ley TJ. Advances in

thalassemia research. Blood 19X4; 63(4): 73X-

X.

Saleem M. Ahmed S. Khattak MF. An overview

of thalassaemia in Pakistan. 4U| International

Conference. Peshawar: Pakistan Association of

Pathologists. 1996: 76.

Alter BP. Prenatal diagnosis of

haemoglobinpathies and other hematologic

diseases. J Pediatr 1979; 95(4): 501-1.3.

Saleem M. Thalassaemia in Pakistan. In: One Day

Symposium on Thalassaemia in Pakistan. Lahore:

Pakistan Thalassaemia Welfare Society. 1991: 1-

JAMC, Vol. 12, No. 2, 2000

Tassiopoulos T, Stamatelos G. Zakopoulos N.

Fessas P. Eliopoulos GD. Lou incidence of acute

myocardial infarction in beta-thalassaemia trait

carriers. Haematological Budap 1995: 26(4): 199-

kaminska M. Badzio T. ksiezopolskakaczorowska. A Bako W. Boj E. Przymanowski

Z. High-molecular weight lipoprotein

concentrations in pneumonia in children and

experimental animals. Probl Med Wieku Rozwoj

: 12: 363-75.

Harbige S. Nutrition and immunity with emphasis

on infection and autoimmune disease. Nutr Health

: 10(4); 2X5-312.

X. Griffith JF, king AD. Chan YL. Clinics in

diagnostic imaging. Singapore Med J 1997. 38(9):

-404.

Livrea MA, Tesoriere L. Pintaudi AM. et al.

Oxidative stress and antioxidant status in (5-

thalassemia major: Iron overload and depletion of

lipid-soluble antioxidants. Blood 1996: 88(9):

-3614.

Giardini O. Murgia F. Martino E. Mannarino O.

Corrado G, Maggioni G. Serum lipid pattern in

beta-thalassemia Acta Haematol 1978:60(2): 100-

Maioli M. Pettinato S. Cherchi GM. et al. Plasma

lipids in Beta- thalassaemia minor.

Atherosclerosis 1989; 75(2-3): 245-48.

Scutellari PX. Orzincolo C. Franceschini F. Bagni

B. The radiographic appearances following

adequate transfusion in beta-thalassaemia.

Skeletal Radiol 19X9: 17:545-50.

Cazzola M. Pootrakul P. Bergamaschi G. Helpers

HA. Eng M. Finch CA. Adequacy of iron supply

for eiythropropoiesis: in vivo observations in

humans. .1 Lab Clin Med 19X7: 110: 734- 39.

Windier E, Ewers-Grabow L. Thiery .1, Walli A

Seidel D. Greten II. The prognostic value of

hypocholesterolemia in hospitalized patients. Clin

Investing 1994, 72(12): 939-43.

Verdery RB. Goldberg AP. Hypocholesterolemia

as a predictor of death: A prospective study of 224

nursing home residents. J Gerontol 1991:46(3):

MX4-90.

Walter JB, Talbot 1C. Gardner HA et al. Genial

Pathology. 7'1' Ed. London: Churchill

Livingstone, 1996: 806-810.

Ganong WF. Review of Medical Physiology. X

Ed. Stamford: Appleton and Lange. 1997: 815-40

How to Cite

Tayyab, M., Abdullah, M., & Ditta, A. (2000). A STUDY OF SERUM LIPID PATTERN IN THALASSAEMIC PATIENTS. Journal of Ayub Medical College Abbottabad, 12(2). Retrieved from https://demo.ayubmed.edu.pk/jamc/index.php/jamc/article/view/5195

Most read articles by the same author(s)

1 2 > >>