DERMATOFIBROSARCOMA PROTUBERANS --A RARE VARI^ANTOF SOFT TISSUE SARCOMA OF SKIN. AN EXPERIENCE OF TWO CASES AT AYUB TEACHING HOSPITAL COMPLEX (ATHC), ABBOTTABAD
Abstract
An old lady of 58 years' age presented with a huge softtissue mass over left pectoral region which was
gradually increasing in size over the last 5-ycars.
Patient also gives history' of recent appearance of
constant dull pain and low grade fever (<100Fo) for the
last 3-4 months. CT Scan revealed a soil tissue sub
cutaneous mass extending from the dermis downwards
without rib erosion. X-Ray chest clear and USG
abdomen was normal. Excisional biopsy revealed
Dermatofibrosarcoma protuberans. After wound
healing, external radiation on 10Mev electron beam
(Varianclinac-20) with direct anterior field
encompassing nearly upper 2/3 of left chest wall and
delivering a tumor dose of 48 grays at I cm depth in 16
treatments. 3 'A weeks' time as ϵ 300 cgys daily.
The tumor bed can be radiated on cobolt -60 (Mega
voltage beam) with tangential fields to mid line dose
of 60 grays in 30 fractions for 6 weeks
References
Hippocrates The theory and practice of medicine.
Runes DD. Kleman T(eds) Secaucus NJ, Citadel
press 1964
Gloster HM JR..DFSP. J Am. Acad. Dermatol
; 35:355
Gutierrez G. DFSP. Inj. J. Dermatol. 1984; 23:396
Alguacil Garcia A and Go liner JR. Histogenesis of
DFSP an ultra-structural study. Am J Clin. Pathol.
69:427
Eilber FR, Morton Dl and Econoomon JS. The soft
tissue sarcomas, Orlando FL & New York. 1987.
Fletcher CD, Evans BJ, Mekee PH. DFSP. A
clinic-pathological and immuno-histochemical!
study, a review of literature. Histopathology
:9: 921.
Taylor HB. Helwig EB. DFSP A study of II5 cases.
Cancer. 1962.15; 717.
Garg SK, Subbuswamy SG, Lawrie JH. DFSP in
northern Nigeria. A clinicopathoiogical review of
cases. Clin Oncol 1978;4: 113.
. Burkhardt BR, Soule EH, Wink Elman RK et al.
DFSP. A study of 56 cases. Am J. Surg. 1966. 11;
Mcpeak CJ, Druz T, Nicestri AD. DFSP. An
analysis of 86 cases, 5 with metastasis. Ann. Surg.
166; 803.
Rink PA, Habermalz HJ, Loccek H: Effective
radiotherapy in one case of DFSP Starling
Therapies. 1982 158:681.
Hajdu SI: Pathology of soft tissue sarcoma.
Philadelphia Lea and Febiger. 1979.
Kobayashi T el al: a case of Bednar tumor.
dermatology. 1997.195:87.
Eigen GW et al: Bednar tumor occurring in site of
prior immunization. J. Am. Acadmi. Dermatol
40:315.
Hashimoto K, Brownstein Mh Jsceobi FA: DFSP.
Arch. Dermatol 1974 110:874.
Qzzello L & Hamel SJ: the histolytic nature of
DFSP. Tissue culture and electron microscopic
study Am J Clin Pathol 1976 65:136
Cantin J, Meneer JP. Chu PC el al the problem of
local recurrence after surgical excision ann. Surg
168.47
Schieber W. Grham P: an experience with sarcoma
tissue in adults Surgery 1962 52 295
Albright SIT treatment of skin cancer using
multiple modalities J Am Acad Dermatol 1982 7
Hruza GJ Mohs micro graph surgery, oto larygol
Clin. North Am 1990 23 845
Mohs FE & Blanchard L Microscopically
controlled for extra memory pajet's disease arch
Dermatol 1979 115. 706
Rowe DE. Carroll RJ, Dayel long term the
recurrence rate in previously untreated skin cancer
J. Dermatol Surg Oncol 1989 15:315
Radnar D et al. Mohs micrographic surgery for the
treatment of DFSP J. Am. Acad Dermatol 1997 37
Robinson J: DFSP resected by mohs surgery. J Am.
Acad Dermatol 1985. 12:1093
Suit HD. Mankein HJ, wood WO. Props KM. Preoperative, intra operative & post-operative
radiation in the treatment of soft tissue sarcoma.
Cancer. 1985 55: 2659-26667.
Tepper JE, Suit HD. The role of radiotherapy in
soft tissue sarcoma. Cancer invest 1985 3: 587-
Kiel KD, Suit HD Radiation therapy in the
treatment of aggressive fibromatosis (desmoid
tumors). Cancer 1985 54. 2041-2055.
Kinsella TJ, Glastein E. Clinical experience with
i/v radio sanitizers in unresectable sarcoma. Cancer
59 908-915.
Tepper JE, suit HB. radiation therapy alone for
soft tissue sarcoma. Cancer 1985 56: 475.
Atkin L, Garvan Jm. Neuton NT. behaviour and
management of soft tissue sarcoma. Cancer 1963
: 1552
Martin RG. Lindberg RD, Russel WO. Preoperative radiotherapy & surgery in the
management of soft tissue and bone sarcoma. PB
-307 Chicago year book medical publishers
Rosenberg SA. suit HD baker LH et al. Soft tissue
and bone sarcoma in Devita. cancer principle and
practice of oncology. Philadelphia Lippin cortt
pp 1036-1068.
Suit HD proppe KH: Multi-disciplinary decisions
in oncology. Soft tissue sarcoma. New York
Pergoman press 1982.
Suit HD. Proppe KH, Mankin HJ et al: Preoperative radiotherapy for soft tissue sarcoma.
Cancer 1981 47: 2267- 2774.
Meneer GP, cantin J, Chu F et al: Effective of
radiotherapy for soft tissue sarcoma. Cancer 1968.
;391 -397
Mittal D, Emami B. Sapareto S et al., Effects of
combined hyperthermia and radiation on the RIF-1
murine tumor. Cancer 1984 54:2889.
Raney B, Jr.: Soft tissue sarcoma in
adolescent in tibbi CK (ed). Major topics in
adolescent oncology) Mamt Kisco, Future
publishing 1987 PP 221 -240
Downloads
How to Cite
Issue
Section
License
Journal of Ayub Medical College, Abbottabad is an OPEN ACCESS JOURNAL which means that all content is FREELY available without charge to all users whether registered with the journal or not. The work published by J Ayub Med Coll Abbottabad is licensed and distributed under the creative commons License CC BY ND Attribution-NoDerivs. Material printed in this journal is OPEN to access, and are FREE for use in academic and research work with proper citation. J Ayub Med Coll Abbottabad accepts only original material for publication with the understanding that except for abstracts, no part of the data has been published or will be submitted for publication elsewhere before appearing in J Ayub Med Coll Abbottabad. The Editorial Board of J Ayub Med Coll Abbottabad makes every effort to ensure the accuracy and authenticity of material printed in J Ayub Med Coll Abbottabad. However, conclusions and statements expressed are views of the authors and do not reflect the opinion/policy of J Ayub Med Coll Abbottabad or the Editorial Board.
USERS are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author. This is in accordance with the BOAI definition of open access.
AUTHORS retain the rights of free downloading/unlimited e-print of full text and sharing/disseminating the article without any restriction, by any means including twitter, scholarly collaboration networks such as ResearchGate, Academia.eu, and social media sites such as Twitter, LinkedIn, Google Scholar and any other professional or academic networking site.
