TREATMENT OF CONDYLOMA ACUMINA WITH PODOPHYLLOTOXIN VERSUS COMBINATION THERAPY
Abstract
Condyloma acuminata is growing problem due to its resistance to conventionaltreatment, increased recurrence rate and its relationship with carcinoma. We have
designed this study to evaluate the efficacy, adverse effects and immunomadulating
effects of podophyllotoxin as a treatment modality of condyloma acuminate as
compared to podophyllotoxin plus interferon alpha-1 cream. Podophyllotoxin as
monotherapy and its combine1 ion therapy with interferon alpha-1 cream produced
complete response in 40% and 68% while recurrence in 48%> and 20% patients
respectively. Topical podophyllotoxin produced pain and inflammation while after its
combination with interferon alpha-1 cream. The incidence of adverse effects remained
the same. Lymphoblast transformation activity and natural Killer activity were
performed for every patient before either of treatment modalities and after only in case
of combination thereby.
KEY WORDS: Condyloma acuminate podophyllotoxin, interferon alpha-1
Lymphoblast transformation activity, Natural Killer activity.
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