PREVALENCE OF MALIGNANCY IN GOITRE-A REVIEW OF 718 THYROIDECTOMIES

Authors

  • Raja Najum ul Haq
  • Basharat Ali Khan
  • Ishtiaq Ahmed Chaudhry

Abstract

Background: Thyroid malignancies are a heterogeneous group of tumours which show considerable
variability in biological behaviour, histological appearances and response to therapy. Thyroid cancer
is uncommon and represents only 1% of all malignancies. Objective was to determine the prevalence
of malignancy in patients presenting with goitre. This prospective, observational study was
conducted at Department of Surgery, Fauji Foundation Hospital, Rawalpindi from January 1999 to
December 2008. Methods: All patients requiring surgery for goitre were included in the study.
Postoperatively histopathologies of specimens were evaluated in all patients. Results: 718 patients
were operated and post operative histopathology specimens were reviewed. 2.92% of patients were
found to have malignancy. Prevalence of papillary and follicular carcinoma was 33.33% each.
Anaplastic carcinoma was found in 23.81% of patients followed by Hurthle cell carcinoma in 9.53%
of patients. Conclusion: All postoperative thyroid specimens should be subjected to histopathology.
Prevalence of follicular carcinoma and anaplastic carcinoma is relatively higher in our country due to
high incidence of iodine deficiency goitre.
Keywords: Goitre, Malignancy, Prevalence, Carcinoma Thyroid

References

Thomas WEG. Neoplasm's of thyroid gland (including the

solitary nodule). Surg Int 2004;64:296-300.

Qureshi JN, Muneer A, Memon AS, Memon S, Hammad A.

Malignancy in nodular goiter. J Surg Pak 2006;11(2):71-2.

Hanks JB. Thyroid. Townsend CM, Beauchamp RD, Evers

BM, Mattox KL (editors) In: Sabiston's Text Book of Surgery

th ed. Philadelphia: Saunders; 2004;961-2.

Jemal A, Murray T, Samuels A, Ghafoor A, Ward E, Thun MJ.

Cancer statistics, 2003, CA Cancer J Clin 2003; 53:5-26.

Wu HS, Young MT, Ituarte PHG, D'Avanzo A, Duh QY,

Greenspan FS, et al. Death from thyroid cancer of Follicular

cell origin. J Am Coll Surg 2000;191:600-6.

Khairy GA. Solitary thyroid nodule: the risk of cancer and the

extent of surgical therapy. East Afr Med J 2004;81:459-62.

Benzarti S, Miled I, Bassoumi T, Ben Mrad B, Akkari K,

Bacha O, Chebbi MK. Thyroid surgery (356cases): risks and

complications. Rev Laryngol Otol Rhinol (Board) 2002;123

(1):33-7.

Alagic-Smailbegovic J, Kapidzic A, Sutalo K, Resic M, Hadzic

E. Surgical treatment of thyroid gland disease. Med Arh

;59:241-3.

Prades JM, Dumollard JM, Timoshenko A, Chelikh L, Michel

F, Estour B, et al. Multinodular goiter: surgical management

and histopathological findings. Eur Arch Otolaryngol

;259:217-21.

Williams ED. Chernobyl, 15 years later: correlation of clinical,

epidemiological and molecular outcomes. Ann Endocrinol

;64:72-5.

Rossing MA, Voigt LF, Wicklund KG, Daling JR.

Reproductive factors and risk of papillary thyroid cancer in

women. Am J Epidemiol 2000;151:765-72.

Sakoda LC, Horn-Ross PL. Reproductive and menstrual

history and papillary thyroid cancer risk: the San Francisco Bay

Area thyroid cancer study. Cancer Epidemiol Biomarker Prev

;11:51-7.

Memon A, Darif M, Al Saleh K, Suresh A. Epidemiology of

reproductive and hormonal factors in thyroid cancer: evidence

from a case control study in the Middle East. Int J Cancer

;97:82-9.

La Vecchia C, Ron E, Franceschi S, Dal Maso L, Mark SD,

Chatenoud L, et al. A pooled analysis of case-control studies of

thyroid cancer. Oral contraceptives, menopausal replacement

therapy and other female hormones. Cancer Causes Control

;10:157-66.

Duffy BJ, Fitzgerald P. thyroid cancer in childhood and

adolescence: a report on twenty eight cases. Cancer

;10:1018-32.

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Published

2009-12-01

How to Cite

Haq, R. N. ul, Khan, B. A., & Chaudhry, I. A. (2009). PREVALENCE OF MALIGNANCY IN GOITRE-A REVIEW OF 718 THYROIDECTOMIES. Journal of Ayub Medical College Abbottabad, 21(4), 134–136. Retrieved from https://demo.ayubmed.edu.pk/jamc/index.php/jamc/article/view/3164

Issue

Vol. 21 No. 4 (2009): JOURNAL OF AYUB MEDICAL COLLEGE, ABBOTTABAD

Section

ORIGINAL ARTICLE

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