EFFICACY OF FIX DOSE COMBINATION (ATORVASTATIN AND AMLODIPINE) IN TREATMENT OF UNCONTROLLED HYPERTENSION AND DYSLIPIDEMIA
Abstract
Background: The fixed-dose combination containing the antihypertensive agent amlodipine and thestatin, atorvastatin, is the first combination of its kind designed to treat two risk factors for
cardiovascular disease (CVD), i.e., hypertension and dyslipidemia. In this study, blood pressure and
lipid lowering effects of combination of amlodipine and atorvastatin were evaluated in uncontrolled
hypertensive patients. Methods: Thirty patients both male and female in the age group 35-60 years
attending the Hypertensive Clinic of PMRC FJMC suffering from uncontrolled hypertension were
selected. Baseline blood pressure was checked after half hour rest in sitting and standing position using
mercury sphygmomanometer. Blood sample was collected from all patients after overnight fasting for
assessment of serum cholesterol, triglycerides, LDL and HDL cholesterol levels. They were prescribed
with fixed dose combination of 5 mg amlodipine and 10 mg atorvastatin. Patients were followed for
their blood pressure measurement after every 4 weeks up to 12 weeks. At the end of 12 weeks their
fasting blood sample was taken again for determination of serum cholesterol, triglyceride, LDL and
HDL cholesterol levels. Results: Systolic blood pressure after 4, 8 and 12 weeks was significantly
lower at all intervals from baseline. When systolic blood pressure after 8 and 12 weeks was compared
with 4 weeks, the effect was again significant (p=0.024, p=0.002 respectively).There was no significant
reduction seen in 8 versus 12 weeks (p=0.493). Diastolic blood pressure at 4, 8 and 12 weeks was
significantly lower from baseline. Diastolic blood pressure after 4 and 8 weeks when compared with 8
and 12 weeks was not significantly low (p=0.99 and 0.91 respectively). Lipid profile of the patients was
significantly reduced from baseline after twelve weeks of fixed dose combination of treatment
(p<0.000). Conclusion: Combination therapy proved to be effective in controlling hypertension and
dyslipidemia than single pill. It also improved patient's compliance. It is suggested that polypill should
be prescribed instead of multiple drugs.
Keywords: combination therapy, atorvastatin, amlodipine, uncontrolled hypertension, dyslipidemia
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