DISSEMINATED INTRAVASCULAR COAGULATION
Abstract
Background: Disseminated Intravascular Coagulation (DIC) is a complex systemic thrombohaemorrhagic disorder characterised by widespread endothelial damage. Aim of this study was to assessthe prevalence of DIC in different obstetrical conditions. Methods: This descriptive study was carried
out in the Department of Obstetrics and Gynaecology Unit '˜A', Ayub Medical College, Abbottabad from
January 2010 to December 2011. All 40 diagnosed cases of DIC were included, and their risk factors and
maternal/foetal outcome were evaluated. Results: Out of 4,334 obstetrical admissions, DIC was
diagnosed in 40 (0.92%) patients. Risk factors noted were eclampsia 28 (70%), abruptio placentae 7
(17.5%), septicaemia 3 (7.5%), pancytopenia 1 (2.5%), and 1 (2.5%) patient had DIC secondary to
haemorrhagic shock due to placenta previa. Mean age range of patients was 31±6.69 (19-48) year, and
parity was 3.17±2.56 (0-10). Mode of delivery of 34 (85%) patients was by caesarean section, and
vaginal delivery occurred in 3 (7.5%) patients. Eleven (27.5%) patients had caesarean hysterectomy.
Maternal mortality was 25% and perinatal mortality was (47.5%). Majority of our patients were critical
and were managed in ICU. Conclusion: DIC is serious life threatening condition secondary to any
underlying pathology. There is spontaneous resolution of DIC after correction of pathology.
Keywords: DIC, Eclampsia, Abruptio placentae, placenta previa, haemorrhagic shock
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