• Kefi Iqbal
  • Maria Asmat


Mercury is known to be a toxic material with adverse effects on the body as claimed by so manyresearchers and always projected a negative aspect of this element. It is true that it may cause a severalproblems when it exceeds the safe limit but along with its negative image, mercury has been playing apositive role in the field of medicine and dentistry. It has many therapeutic uses including variousmedications, ointments, dental fillings, contact lens, cosmetics, paints as well as in different instrumentslike thermometer and sphygmomanometers. Mercury and its compounds used in dental practice may beresponsible for release of mercury into the oral cavity. Compounds of mercury tend to be much moretoxic than the element itself, and organic compounds of mercury (e.g., dimethyl-mercury) are oftenextremely toxic and may be responsible in causing brain and liver damage.Keywords: Mercury uses, Mercury toxicity, Dental amalgam, Elemental mercury, Dimethyl mercury


Grimes IC, Einarsson S, Spier BJ, Reichelderfer M. Mercury

ingestion retrieved by colonoscopy. Gastrointest Endosc


Grolier JPE, Dan F. The use of advanced calorimetric techniques

in polymer synthesis and characterization. Thermochim Acta


Fu Z, Wu F, Amarasiriwardena D, Mo C, Liu B, Zhu J, et al.

Antimony, arsenic and mercury in the aquatic environment and

fish in a large antimony mining area in Hunan, China. Sci Total

Environ 2010;408:3403–10.

Kristi L. Understanding the element of the periodic table Hg. 1st

ed. USA: Rosen Publishing Group; 2009.p 17.

World Health Organization International Programme on

Chemical Safety (WHO IPCS). Concise International Chemical

Assessment Documents 50. Elemental mercury and inorganic

mercury compounds human health aspects; 2003 Report.

available at

Hylander LD, Meili M. 500 Years of mercury production global

annual inventory by region until 2000 and associated emissions.

Sci Total Environ 2003;304:13–47.

Emsley J. The element of murder, 1st ed. New York: Oxford

University Press Inc; 2005.p. 48.

Gochfeld M. Cases of mercury exposure, bioavailability, and

absorption. Ecotoxicol Environ Saf 2003;56:174–9.

Clifton JC 2nd. Mercury exposure and public health. Pediatr Clin

North Am 2007;54(2):237–69.

Bose-O'Reilly S, McCarty KM, Steckling N, Lettmeier B.

Mercury exposure and children health. Curr Probl Pediatr

Adolesc Health Care 2010;40(8):186–215.

Goldman LR, Shannon MW. American Academy of Pediatrics:

Committee on Environmental Health. Technical report: Mercury

in the environment: implications for pediatricians. Pediatrics


Guzzi G, La Porta CA. Molecular mechanisms triggered by

mercury. Toxicology 2008;244(1):1–12.

Dyall-Smith DJ, Scurry JP. Mercury pigmentation and high

mercury levels from the use of a cosmetic cream. Med J Aust


Weinstein M, Bernstein S. Clinical Vistas: Pink ladies: mercury

poisoning in twin girls. CMAJ 2003;168:201.

O’Shea JG. Two minutes with venus, two years with mercury –

mercury as an antisyphilitic chemotherapeutic agent. J R Soc

Med 1990;83:392–5.

Bruce AF, Margaret HW, Carl GE. Mercury induced renal

effects. J Clin Nephrotox 2008;3:811–26.

Boyd AS, Seger D, Vannucci S, Langley M, Abraham JL, King

LE Jr. Mercury exposure and cutaneous disease. J Am Acad

Dermato 2000;43:81–90.

Yoshida M, Satosh M, Shimada A, Yamamoto E, Yasutake A.

Maternal-to-fetus transfer of mercury in metallothionein-null

J Ayub Med Coll Abbottabad 2012;24(3-4) 207

pregnant mice after exposure to mercury vapour. Toxicol Pathol


Dadzie OE, Petit A. Skin bleaching: highlighting the misuse of

cutaneous depigmenting agents. J Eur Acad Dermatol Venereol


Counter SA, Buchanan LH. Mercury exposure in children: a

review. Toxicol Appl Pharmacol 2004;198:209–30.

Tan M, Parkin JE. Route of decomposition of thimerosal. Int J

Pharm 2000;208:23–34.

Geier DA, Sykes LK, Geier MR. A review of Thimerosal

(Merthiolate) and its ethylmercury breakdown product: specific

historical considerations regarding safety and effectiveness. J

Toxicol Environ Health B Crit Rev 2007;10:575–96.

Young HA, Geier DA, Geier MR. Thimerosal exposure in infants

and neuro developmental disorders: An assessment of

computerized medical records in the Vaccines Safety Data link. J

Neurol Sci 2008;271(1-2):110–8.

Rennels M, King JJ, Ryall R, Papa T, Froeschle J. Dosage

Escalation, Safety and Immunogenicity Study of Four Dosages of

a Tetravalent Meninogococcal Polysaccharide Diphtheria Toxoid

Conjugate Vaccine in Infants. J Pediatr Infect Dis


Gosselin RE, Smith RP, Hodge HC, (Eds). Clinical Toxicology

of Commercial Products. (5th ed). Baltimore: Williams and

Wilkins; 1984. p. 267.

Castoldi AF, Onishchenko N, Johansson C, Coccini T, Roda E,

Vahter M, et al. Neurodevelopmental toxicity of methylmercury:

Laboratory animal data and their contribution to human risk

assessment. Regul Toxicol Pharmacol 2008;51:215–29.

Halbach S, Vogt S, Köhler W, Felgenhauer N, Welzl G, Kremers


, et al. Blood and urine mercury levels in adult amalgam

patients of a randomized controlled trial: Interaction of Hg

species in erythrocytes. Environ Res 2008;107:69–78.

Ye X, Qain H, Xu P, Zhu L, Longnecker MP, Fu H.

Nephrotoxicity, neurotoxicity, and mercury exposure among

children with and without dental amalgam fillings. Int J Hyg

Environ Health 2009;212:378–86.

Thomas WC, Laszlo M. The Toxicology of Mercury and Its

Chemical Compounds. Crit Rev Toxicol 2006;36:609–62.

The safety of dental amalgam and alternative dental restoration

materials for patients and users. Scientific Committee on

Emerging and Newly Identified Health Risks SCENIHR. The

SCENIHR adopted this opinion via written procedure on 6 May

, after consultation. Available at:


Ozdabak HN , Serpil K, lanog L, Nilgu A , Fevzi P, Nilgu. The

effects of amalgam restorations on plasma mercury levels and

total antioxidant activity. Arch Oral Biol 2008;531:1101–6.

WHO (World Health Organisation).Mercury in drinking water.

Back ground document for development of WHO guidelines for

Drinking water Quality. Document WHO/SDE/WSH/05.08/10,

Geneva, World Health Organisation. Available at:

World Health Organization, Environmental Health Criteria 118:

Inorganic mercury, Geneva, 1991. Published under the joint

sponsorship of the United Nations Environment Programme, the

International Labour Organisation, and the World Health

Organization First draft prepared by Dr. L. Friberg, Karolinska

Institute, Sweden World Health Orgnization Geneva, 1991.

Dental Amalgam: Myths vs Facts CHICAGO, 2002 Americian

Dental Association.


Holmes P, James KAF, Levy LS, Is low level environmental

mercury exposure of concern to human health. Sci Total Environ


Caravati EM, Erdman AR, Christianson G, Nelson LS, Woolf

AD, Booze LL, et al. Elemental mercury exposure: An evidencebased consensus guideline for out-of-hospital management. Clin

Toxicol (Philla) 2008;46(1):1–21.

EU (European Union Employment and Social Affairs. Health

and Safety at Work). Recommendation from the Scientific

Committee on occupational exposure limits for elemental

mercury and inorganic divalent mercury compounds; 2007.

Available at:


Boadi WY, Urbach J, Brandes JM, Yannai S. In vitro effect of

mercury on enzyme activities and its accumulation in the firsttrimester human placenta. Environ Res 1992;57:96–106.

Tchounwou PB, Ayensu WK, Ninashvili N, Sutton D.

Environmental exposure to mercury and its toxicopathologic

implications for public health. Environ Toxicol 2003;18:149–75.

Murphy J, Jones P, Hill SJ. Determination of total mercury in

environmental and biological samples by flow injection cold

vapour atomic absorption spectrometry. Spectrochimica Acta

Part B 1996;51:1867–73.

Joshi D, Mittal DK, Shukla S, Srivastav AK.Therapeutic

potential of N acetylcysteine with antioxidants (Zn and Se)

supplementation against dimethylmercury toxicity in male albino

rats. Exp Toxicol Pathol 2012;64(1–2):103–8.

Siegler RW, Nierenberg DW, Hickey WF. Fatal poisoning from

liquid dimethylmercury: A neuropathology study. Hum Path


Nierenberg DW, Nordgren RE, Chang MB, Siegler RW,

Blayney MB, Hochberg F, et al. Delayed Cerebellar Disease and

Death after accidental exposure to dimethylmercury. N Engl J

Med 1998;338:1672–6.

Blayney MB, JS Winn, and DW Nierenberg. “Letters; Chemical

Safety-Handling Dimethylmercury” Chemical and Engineering

News (1997, May 12):7.

US Environmental Protection Agency. Summary Review of

Health Effects Associated with Mercuric Chloride: Health Issue

Assessment. EPA/600/R-92/199. Office of Health and

Environmental Assessment, Washington, DC. 1994.

Bidstrup PL (Ed) Toxicity of mercury and its compounds.

Amsterdam: Elsevier; 1964.p. 8–14.

Oslon KR (Ed). Poisiong and Drug Overdose. 4th ed. USA:

McGraw Hill; 2003. p. 254.

Newland MC, Elliott MP, Miranda NR. Methylmercury and

nutrition: Adult effects of fetal exposure in experimental models.

Neurotoxicology 2008;29(5):783–801.