MARKED ACANTHOCYTOSIS ASSOCIATED WITH KLIPPLE-TRENAUNAY SYNDROME
DOI:
https://doi.org/10.55519/JAMC-01-11307Keywords:
Klipple Trenaunay Syndrome, Acanthocytosis, Arteriovenous malformation, Skin hypertrophyAbstract
Klipple-Trenaunay syndrome (KTS) is an extremely rare congenital vascular disorder with poorly defined incidence and prevalence. We report a case of a patient who presented after road traffic accident with primary complaints of poor wound healing and persistent bleeding from wound site. Discernible presence of arteriovenous malformation and skin hypertrophy since birth lead to the diagnosis of Klipple-Trenaunay syndrome (KTS). There was an incidental finding of acanthocytosis on peripheral film of blood which remained elevated even after clinical improvement of the patient. This case report highlights a close association of marked acanthocytosis of red blood cells and Klipple-Trenaunay syndrome.
References
Müller-Wille R, Wildgruber M, Sadick M, Wohlgemuth WA. Vascular anomalies (part II): interventional therapy of peripheral vascular malformations. RöFo 2018;190(10):927-37.
Karunamurthy A, Pantanowitz L, Lepe JG, Reyes-Múgica M. Lethal outcomes in Klippel-Trenaunay syndrome. Pediatr Dev Pathol 2013;16(5):337-42.
Oduber C, Van Beers E, Bresser P, Van der Horst C, Meijers J, Gerdes V. Venous thromboembolism and prothrombotic parameters in Klippel-Trenaunay syndrome. Neth J Med 2013;71(5):246-52.
Horbach S, Lokhorst M, Oduber C, Middeldorp S, van der Post J, van der Horst C. Complications of pregnancy and labour in women with Klippel-Trénaunay syndrome: a nationwide cross-sectional study. BJOG 2017;124(11):1780-8.
Yasumoto A, Ishiura R, Narushima M, Yatomi Y. Successful treatment with dabigatran for consumptive coagulopathy associated with extensive vascular malformations. Blood Coagul Fibrinolysis 2017;28(8):670-4.
Dompmartin A, Acher A, Thibon P, Tourbach S, Hermans C, Deneys V, et al. Association of localized intravascular coagulopathy with venous malformations. Arch Dermatol 2008;144(7):873-7.
Palmer L, Briggs C, McFadden S, Zini G, Burthem J, Rozenberg G, et al. ICSH recommendations for the standardization of nomenclature and grading of peripheral blood cell morphological features. Int J Lab Hematol 2015;37(3):287-303.
Salvioli G, Rioli G, Lugli R, Salati R. Membrane lipid composition of red blood cells in liver disease: regression of spur cell anaemia after infusion of polyunsaturated phosphatidylcholine. Gut 1978;19(9):844-50.
Storch A, Kornhass M, Schwarz J. Testing for acanthocytosis A prospective reader-blinded study in movement disorder patients. J Neurol 2005;252(1):84-90.
Naganathan S, Tadi P. Klippel Trenaunay Weber Syndrome. 2022 Jul 19. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022.
Withana M, Rodrigo C, Shivanthan MC, Warnakulasooriya S, Wimalachandra M, Gooneratne L, et al. Klippel-Trenaunay syndrome presenting with acanthocytosis and splenic and retroperitoneal lymphangioma: a case report. J Med Case Rep 2014;8:390.
Cruz H, Ferreira AM, Costa E, Barbot J, Freitas MI. Marked acanthocytosis in the setting of Klippel-Trenaunay syndrome: A case report. Int J Lab Hematol 2019;41(1):e10-2.
Downloads
Published
How to Cite
Issue
Section
License
Journal of Ayub Medical College, Abbottabad is an OPEN ACCESS JOURNAL which means that all content is FREELY available without charge to all users whether registered with the journal or not. The work published by J Ayub Med Coll Abbottabad is licensed and distributed under the creative commons License CC BY ND Attribution-NoDerivs. Material printed in this journal is OPEN to access, and are FREE for use in academic and research work with proper citation. J Ayub Med Coll Abbottabad accepts only original material for publication with the understanding that except for abstracts, no part of the data has been published or will be submitted for publication elsewhere before appearing in J Ayub Med Coll Abbottabad. The Editorial Board of J Ayub Med Coll Abbottabad makes every effort to ensure the accuracy and authenticity of material printed in J Ayub Med Coll Abbottabad. However, conclusions and statements expressed are views of the authors and do not reflect the opinion/policy of J Ayub Med Coll Abbottabad or the Editorial Board.
USERS are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author. This is in accordance with the BOAI definition of open access.
AUTHORS retain the rights of free downloading/unlimited e-print of full text and sharing/disseminating the article without any restriction, by any means including twitter, scholarly collaboration networks such as ResearchGate, Academia.eu, and social media sites such as Twitter, LinkedIn, Google Scholar and any other professional or academic networking site.