EFFECTS OF '˜OLEA EUROPEA' EXTRACT ON VOLUME AND ACIDITY OF CARBACHOL INDUCED GASTRIC SECRETION, LIVER AND KIDNEY FUNCTION IN RABBITS
Abstract
Background: Peptic ulcer is mostly produced due to the over production of gastric acid. This study wasundertaken to find out the effects of extract from the leaves of medicinal plant Olea europea (which
contains documented natural Calcium channel blocker) on volume and acidity of Carbachol induced
gastric section. Its effects were also observed on liver and kidney function. Methods: Thirty rabbits of
local breed, weighing 1-1.5 kg were used. The animals were kept on fasting for 48 hours, after that the
pylorus of each animal was ligated. Carbachol 600 μg/kg body weight and extract from the leaves of
Olea europea 500 mg/kg body weight were administered intraperitoneally to group A and B
respectively. The extract was also administered in the same dose to group C for 45 days twice daily
intraperitoneally to observe its effects on liver and kidney function. Results: The extract reduced the
volume, free and total acidity of gastric secretion, which were statistically highly significant when
compared with Carbachol (p<0.001). When the differences of means for both the liver and kidney
function were compared with that of control group, all these were found statistically non-significant
indicating that the extract has no adverse effects on these organs regarding all parameters included in
study. Conclusion: Extract can be used effectively and safely in the treatment of hyper gastric acidity
conditions and peptic ulcer after evaluation of its effects in human subjects.
Keywords: Medical plants, Olea Europea
References
Edward CRW, Bouchier IAD, Haslett C. Diseases of the
stomach. In: Davidson's Principles and Practice of Medicine,
London: Churchill Livingstone; 1995.p.425-34.
Azhar I, Aftab K, Usmanghani K. Naturally occurring calcium
channel blockers. Hamdard Med 1995;38(2):5-16.
Rauwald HW, Brehm O. Screening of some medicinal plants for
their possible calcium antagonistic activity. Planta Med
;57(2):A59-A60.
Basso N, Materia A, Folini A, Jafe BM. Prostaglandin generation
in the gastric mucosa of rats with stress ulcer. Surgery
;94:104-8.
Passaro E J, Basso N, Walsh JH. Calcium challenge in
Zollinger-Ellision syndrome, Surgery 1972;72:60-7.
Vischer FE, Seay PH, Tazelaar AP, Veldkamp J W, Brook MJ.
Pharmacology of pamine Bromide. J Pharmacol Expt Ther
;110:188-204.
Varley H. Test of gastric function, occult blood. In practical
clinical biochemistry, London: Willium Meinmann; 1962.p.
-77.
Shambuerk RD, Schubert ML. Control of gastric acid secretion.
Gastroenterol Clin North Am 1992;21(3):527-50.
Negulescu PA, Matchen TE. Intracellular calcium regulation
during secretogogues stimulation of the parietal cells. Am J
Physiol 1988;254:130-40.
Brogden RN, Carmine AA, Heel RC, Speight TM, Avery GS.
Ranitidine: A review of its pharmacology and therapeutic use
in peptic ulcer disease and other allied diseases. Drug
;24:267-303.
Brage R, Cortijo J, Esplugues JK, Esplugues J, Bomnati EM,
Rondriguez C. Effects of calcium channel blockers on gastric
emptying and acid secretion of the rat in vivo. Br J Pharmacol
;89:627-33.
Kirkegaard P, Charistianson J, Peterson B, Olsen PS. Calcium
and stimulus-secretion coupling in gastric fundic mucosa: effect
of inhibition of calcium transport by verapamil on gastric acid
secretion in the isolated guinea pig fundic mucosa and in healthy
subjects. Scand J Gastroenterol 1982;17:533-8.
Rogers C, Pihan G, Szabo S. Role of leukotrienes in the
pathogenesis of haemorrhagic gastric mucosal lesions induced by
ethanol or HCL in the rat. Gastroenterol 1986; 90:1797.
Main IHM, Pearce JB. Effects of calcium on acid secretion from
the rat isolated gastric Mucosa during stimulation with histamine,
pentagastrin, methacholine, and dibutyrl cyclic adenosine-3,5-
monophosphate. Br J Pharmacol 1978;64:359-68.
Downloads
Published
How to Cite
Issue
Section
License
Journal of Ayub Medical College, Abbottabad is an OPEN ACCESS JOURNAL which means that all content is FREELY available without charge to all users whether registered with the journal or not. The work published by J Ayub Med Coll Abbottabad is licensed and distributed under the creative commons License CC BY ND Attribution-NoDerivs. Material printed in this journal is OPEN to access, and are FREE for use in academic and research work with proper citation. J Ayub Med Coll Abbottabad accepts only original material for publication with the understanding that except for abstracts, no part of the data has been published or will be submitted for publication elsewhere before appearing in J Ayub Med Coll Abbottabad. The Editorial Board of J Ayub Med Coll Abbottabad makes every effort to ensure the accuracy and authenticity of material printed in J Ayub Med Coll Abbottabad. However, conclusions and statements expressed are views of the authors and do not reflect the opinion/policy of J Ayub Med Coll Abbottabad or the Editorial Board.
USERS are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author. This is in accordance with the BOAI definition of open access.
AUTHORS retain the rights of free downloading/unlimited e-print of full text and sharing/disseminating the article without any restriction, by any means including twitter, scholarly collaboration networks such as ResearchGate, Academia.eu, and social media sites such as Twitter, LinkedIn, Google Scholar and any other professional or academic networking site.
