ASSOCIATION OF ABO AND RH BLOOD GROUP TYPES TO HEPATITIS B, HEPATITIS C, HIV AND SYPHILLIS INFECTION, A FIVE YEAR' EXPERIENCE IN HEALTHY BLOOD DONORS IN A TERTIARY CARE HOSPITAL

Authors

  • Zufishan Batool Rehman Medical College, Rehman Medical Institute
  • Saadia Haroon Durrani
  • Shazia Tariq

Abstract

Background: Aim of the study: The aim of the study was to find out the frequency of Hepatitis B Hepatitis C, Syphilis, HIV and malaria in apparently healthy blood donors and to find out any association between ABO and Rh blood groups. Methods: It was a descriptive study carried out at Rehman Medical Institute laboratory. All blood donors who volunteered for blood donation from Jan 2008 to Dec 2014 were reviewed for blood groups and screening tests. Those who were eligible were then screened for Hepatitis B, Hepatitis C, HIV, syphilis and malaria on Architect 8200i through chemiluminescent immunoassay whereas malaria was screened by a thin film. Blood group was determined by both forward and reverse grouping. Statistical analysis was carried out using SPSS software and expressed as frequencies. Results: A total of 41033 apparently healthy donors were included in the study. All of them were voluntary donors. Their age ranged from 18-70 years with a mean age of 38±10.5years. Out of these 41033, 40245 (98.3%) were males and 788(1.9%) were females. The most frequent blood group was B positive followed by O positive. Out of 41033 donors 961 (2.30%) had Hepatitis B, 566 (1.30%) had Hepatitis C, 363 (0.90%) had syphilis, 311 (0.76%) had malaria and 30 (0.07%) had HIV. There is a significant association between A blood group and HIV and hepatitis B. Donors with blood group O had no significant association with any blood transmitted infection. Conclusion: Blood group O may have some influence in protecting against blood transmitted infection. People having Blood group A are more prone to get Hepatitis B and HIV

Keywords: Treponema pallidum; chemiluminescent immunoassay; Architect; Syphilis

Author Biography

Zufishan Batool, Rehman Medical College, Rehman Medical Institute

Pathology Department RMC, Assistant Professor

References

Reid ME, Bird GW. Associations between human red cell blood group antigens and disease. Transfus Med Rev1990;4(1):47-55.

Pinkston JA, Cole P. ABO blood groups and salivary gland tumors (Alabama, United States) 1996; Cancer Causes Control: 7(6):572-4

Aird I, Bentall HH, Mehigan JA, Roberts JA. The Blood Groups in Relation to Peptic Ulceration and Carcinoma of Colon, Rectum, Breast, and Bronchus; an association between the ABO group and peptic ulceration. Br Med J 19542(4883):315-21.

Tyagi SP, Tiagi GK, Pradhan S. ABO blood groups in relation to cancer cervix. Indian J Med Sci 1967;2:611-5.

Ahmad J, Taj AS, Rahim A, Shah A, Rehman M. Frequency of Hepatitis B and Hepatitis C in healthy blood donors of NWFP: a single center experience. J Postgrad Med Inst 2011;18(3):343-52.

Hafeez-ud-din, Siddiqui TS, Lahrasab W, Sharif MA. Prevalence of hepatitis B and C in healthy adult males of paramilitary personnel in Punjab. J Ayub Med Coll Abbottabad 2012;24(3-4):138-40.

Mumtaz S. Frequency of seropositive blood donors for hepatitis B, C and HIV viruses in railway hospital Rawalpindi. Pak J Med Res 2002;41(2):51-3.

Attaullah S, Khan S, Khan J. Trend of transfusion transmitted infections frequency in blood donors: provide a road map for its prevention and control. J Transl Med 2012;10:20.

Gerbase AC, Rowley JT, Heymann DH, Berkley SF, Piot P. Global prevalence and incidence estimates of selected curable STDs Sex Transm Infect 1998;74(Suppl 1):S12-6.

Mohammad F, Pourfathollah A. Association of ABO and Rh Blood Groups to Blood-Borne Infections among Blood Donors in Tehran-Iran. Iran J Public Healt 2014;43(7):981-9.

Aird I, Bentall HH, Roberts JA. Relationship Between Cancer of Stomach and the ABO Blood Groups Br Med J 1953;1(4814):799-801.

Khattak ID, Khan TM, Khan P, Shah SM, Khattak ST, Ali A. Frequency of abo and rhesus blood groups in district swat, Pakistan. J Ayub Med Coll Abbottabad 2008;20(4):230-7.

Das PK, Nair SC, Harris VK , Rose D, Mammen JJ, Bose YN, et al. A Distribution of ABO and RhD blood groups amongblood donor in a tertiary care centre in South India. Trop Doct 2001;31(1):47-8.

Tomilan VV, Gurtovaia SV. The incidence of finding ABO system antigens in the population of the Russian Federation. Sud Med Ekspert 1999;42(3):16-8.

Gao S, Worm J, Guldberg P, Eiberg H, Krogdahl A, Liu CJ, et al. Genetic and epigenetic alterations of the blood group ABO gene in oral squamous cell carcinoma. Int J Cancer 2004;109(2):230-7.

Wolpin BM, Kraft P, Gross M, Helzlsouer K, Bueno-de-Mesquita HB, Steplowski E, et al. Pancreatic cancer risk and ABO blood group alleles: results from the pancreatic cancer cohort consortium. Cancer Res 2012;70(3):1015-23.

Amundadottir L, Kraft P, Stolzenberg-Solomon RZ, Fuchs CS, Petersen GM, Arslan AA, et al. Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer. Nat Genet 2010;41(9)986-90.

Fahud DD, Mohebb MA, Farhud I, Khavari-Khorasani H. ABO and Rh blood in Cardiovascular Disease from Iran. Iran J Public Health 1992;21(1-4):1-10.

BO D, Fy A. Relationship of blood groups to disease: do blood groups antigens have a biological role. Rev Med Inst Mex Senguro Soc 2005;43(Suppl 1):113-21.

Dentali F, Sironi AP, Ageno W, et al. ABO blood group and vascular disease: an update. Semin Thromb Hemost 2014; 40:49-59.

Li B, Tan B, Chen C, Zhao L, Qin L. Association between the ABO blood group and risk of common cancers. J Evid Based Med 2014;7(2):79-83.

Downloads

Published

2017-01-25

How to Cite

Batool, Z., Durrani, S. H., & Tariq, S. (2017). ASSOCIATION OF ABO AND RH BLOOD GROUP TYPES TO HEPATITIS B, HEPATITIS C, HIV AND SYPHILLIS INFECTION, A FIVE YEAR’ EXPERIENCE IN HEALTHY BLOOD DONORS IN A TERTIARY CARE HOSPITAL. Journal of Ayub Medical College Abbottabad, 29(1), 90–92. Retrieved from https://demo.ayubmed.edu.pk/index.php/jamc/article/view/1729

Issue

Vol. 29 No. 1 (2017): JOURNAL OF AYUB MEDICAL COLLEGE, ABBOTTABAD

Section

ORIGINAL ARTICLE

License

Journal of Ayub Medical College, Abbottabad is an OPEN ACCESS JOURNAL which means that all content is FREELY available without charge to all users whether registered with the journal or not. The work published by J Ayub Med Coll Abbottabad is licensed and distributed under the creative commons License  CC BY ND Attribution-NoDerivs. Material printed in this journal is OPEN to access, and are FREE for use in academic and research work with proper citation. J Ayub Med Coll Abbottabad accepts only original material for publication with the understanding that except for abstracts, no part of the data has been published or will be submitted for publication elsewhere before appearing in J Ayub Med Coll Abbottabad. The Editorial Board of J Ayub Med Coll Abbottabad makes every effort to ensure the accuracy and authenticity of material printed in J Ayub Med Coll Abbottabad. However, conclusions and statements expressed are views of the authors and do not reflect the opinion/policy of J Ayub Med Coll Abbottabad or the Editorial Board.

USERS are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author. This is in accordance with the BOAI definition of open access.

AUTHORS retain the rights of free downloading/unlimited e-print of full text and sharing/disseminating the article without any restriction, by any means including twitter, scholarly collaboration networks such as ResearchGate, Academia.eu, and social media sites such as Twitter, LinkedIn, Google Scholar and any other professional or academic networking site.