EFFECT OF TAMOXIFEN ON PLASMA ARGININE VASOPRESSIN LEVELS
Abstract
Ovariectomy of the mature female rat results in a fall in the plasma vasopressin concentrationalthough the ovarian content of the hormone is low. To investigate this further, functional ovariectomy wasdone in the rats by administration of an antioestrogen acting drug (Tamoxifen).Studies performed on female rats indicated significant reductions in uterine weight and plasmavasopressin levels.The uterine weights decreased from 206.9 mg 1100 gm body weight in control group to 142.2 mg/100 gm body weight in experimental group.Plasma vasopressin levels decreased from 1.15 microunits /ml in the control group to 0.38microunits /ml in the experimental group.The study confirms that like surgically ovariectomized rats, Junctional ovariectomy also causesdecreases in uterine weights and plasma vasopressin levels.References
Al Sendi A, Forsling ML, Khan M & Peysner K. Fluid
balance in cycling rats and ovariectomized rats treated with
oestradiol benzoate. Journal of Physiology, 1985, 371: 189
Dignam WS, Voskain J & Assali NS. Effects of oestrogens
on renal hemodynamics and excretion of electrolytes in
human subjects. Journal of Clinical Endocrinology &
Metabolism, 1956, 16: 1032 - 1041
Butcher RL, Collins WE & Fugo NW. Plasma
concentrations of LH, FSH, prolactin, progesterone &
oestradiol-17B throughout the 4-days oestrous cycle of the
rat. Endocrinology, 1974, 94: 1704- 1707
De Vries GJL, Buijs RM & Sluiter AA. Gonadal hormone
action on the morphology of the vasopressinergic
innervation of the adult rat brain. Brain Research, 1984, 298:
-145
Forsling JML, Akerlund M & Stromberg P. Variation in
plasma concentrations of vasopressin during the menstrual
cycle. Journal of Endocrinology, 1981, 89: 263-266
Windle R, Samuels L, Williams E & Forsling ML. Journal
of Endocrinology, 1988, 119 (suppl): 37
Guzick J, Wang DY & Bulbrook RD. The prevention of
breast cancer. Lancet, 1986, i: 83-86.
Wakeling AE & Slater SR. Cancer Treatment Reports,
June/July 1980, Vol 64, No. 67.
Wade GN, Blaustein JD, Gray JM & Meredith JM.
ICI182780, a pure anti-oestrogen that affects behaviour and
energy balance in rats without acting in brain. American
Journal of Physiology, Dec 1993, 265 (6 pt 2) R.: 1392-8.
Batanagar AS, Batzl C, Hausler A & Nogues V. The role of
oestrogen in the feedback regulation of follicle-stimulating
hormone secretion in the female rat. Journal Steroid
Biochem Mol Biol, Dec 1993, 47 (1-6): 161-6.
Morozova DV. Effect of oestrogen on uterus of mice of
different strains. Biull Eksp -Biol -Med, Dec 1991, 112 (12):
-3.
Skowsky WR. Effect of sex steroid hormones on vasopressin
in intact and castrated male and female rat. Endocrinology,
, 104: 105-108.
Khan MA, Khan MUA, Aslam M & Babar MK. Fluid
balance in cycling and ovariectomized rats treated with
oestradiol benzoate. Pak Armed Forces Medical Journal,
, 44 (1): 7-14.
Khan MA, Khan MUA & Aslam M. Food intake and water
retention over the oestrous cycle of the rat treated with
difluoro- methylomithine (DFMO). Pak Armed Forces
Medical Journal, 1995, 45 (1): 50-4.
Moon CY, Wakly GK & Turner RT. Dose dependent effect
of Tamoxifen on long bones in growing rats, influence of
ovarian status. Endocrinology, Sept 1991, 129 (3): 1568-74.
Downloads
Issue
Section
License
Journal of Ayub Medical College, Abbottabad is an OPEN ACCESS JOURNAL which means that all content is FREELY available without charge to all users whether registered with the journal or not. The work published by J Ayub Med Coll Abbottabad is licensed and distributed under the creative commons License CC BY ND Attribution-NoDerivs. Material printed in this journal is OPEN to access, and are FREE for use in academic and research work with proper citation. J Ayub Med Coll Abbottabad accepts only original material for publication with the understanding that except for abstracts, no part of the data has been published or will be submitted for publication elsewhere before appearing in J Ayub Med Coll Abbottabad. The Editorial Board of J Ayub Med Coll Abbottabad makes every effort to ensure the accuracy and authenticity of material printed in J Ayub Med Coll Abbottabad. However, conclusions and statements expressed are views of the authors and do not reflect the opinion/policy of J Ayub Med Coll Abbottabad or the Editorial Board.
USERS are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author. This is in accordance with the BOAI definition of open access.
AUTHORS retain the rights of free downloading/unlimited e-print of full text and sharing/disseminating the article without any restriction, by any means including twitter, scholarly collaboration networks such as ResearchGate, Academia.eu, and social media sites such as Twitter, LinkedIn, Google Scholar and any other professional or academic networking site.
