PERIPHERAL OSSIFYING FIBROMA OF ORAL CAVITY: HISTOPATHOLOGIC DIFFERENTIAL DIAGNOSES
Abstract
Peripheral ossifying fibroma is a benign neoplasm that usually develops from gingiva, presenting as anexophytic smooth surfaced pink or red nodular mass that is sessile or is less frequently seen on a
pedicle. From the Indian perspective, it is usually noticed in 5th-6th decades of life with female
predilection. Microscopically, the tumour shows stratified squamous epithelium and highly cellular
fibrous stroma, sparse endothelial proliferation with fibroblasts and dystrophic calcifications. It has to
be differentiated histopathologically from pyogenic granuloma, fibroma, peripheral giant cell
granuloma, peripheral odontogenic fibroma and fibrous hyperplasia. A case of peripheral ossifying
fibroma of maxillary gingiva in a 55-year-old Indian woman is reported.
Keywords: Peripheral ossifying fibroma, oral cavity, gingival growth, histopathologic differential
diagnosis
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