IRON STATUS: IS THERE A ROLE IN FEBRILE SEIZURES?

Authors

  • Nadia Waheed
  • Muhammad Asghar Butt

Abstract

Background: Febrile seizure a common convulsion disorder in children, can lead to increased
morbidity and mortality because of risk of aspiration and hypoxia during prolonged febrile seizures.
There are many risk factors associated with febrile seizures and their recurrence. We conducted this
study to see if there is a role of iron status in febrile seizures. Methods: This cross-sectional study was
conducted in 323 children 6 months to 5 years of age admitted in department of Paediatric DHQ
Hospital Faisalabad with fever and seizures from July 2009 to April 2011. Iron deficiency anaemia
including haemoglobin concentration (Hb), Mean Corpuscular Volume (MCV), Mean Corpuscular
Haemoglobin (MCH) and Plasma Ferritin were measured. Results: Febrile seizures were more
common between ages 12 months to 36 months. Of 323 children with febrile seizures 17 (5.3%) were
iron deficient. Mean Hb was 11.71±1.38 g/dL, mean MCV 78.40±3.29, mean MCH 27.11±3.28, and
mean ferritin was 66.57±24.7. Conclusion: Iron deficiency anaemia was not common in patients with
seizures. Iron status has no role in febrile seizures.
Keywords: Iron deficiency anaemia, febrile seizures

References

Steering Committee on Quality Improvement and Management

Sub-committee on Febrile Fits. Clinical practice guidelines.

Febrile seizures: clinical practice guideline for the long term

management of the child with simple febrile seizures. Paediatrics

; 121:1281-6.

Jeffrey R, Butchbalter. Febrile seizure. In: Chapman K, Rho J

(Eds). Paediatric epilepsy case study. New York, USA: CRC

Press Tylor and Frances Group; 2009:87-91.

Stafstorm C. The incidence and prevalence of febrile seizures.

Febrile seizures. Academic Press; 2002:1-25.

Seizure in children. In: Haneef SM, Maqbool S, Arif MA. (edi).

Textbook of paediatrics 5th ed. Lahore: Pakistan paediatrics

Association, 2007: 687-747.

The nervous system. In: Kliegman RM, Behrman RE, Jenson

RB, Stanton BF. Nelson text book of pediatrics 18th ed.

Philadelphia: Saunders 2008:2457-75.

Shinnar S. Febrile seizure. In: Swaiman KF, Ashwal S, Ferriero

DM, (Ed). Paediatric Neurology: Principles & Practice. 4th ed.

Philadelphia: Mosby Elsevier; 2006: p.1079-89.

Haung MC, Haung CC, Thornas K. Febrile convulsion;

development and validation of questionnaire to measure parental

knowledge, attitudes, concerns and practices Formos Med Assoc

;105:38-48.

Abou-Khalil B, Keri L, Lazenby B, Harris PA, Haines JL,

Hedera P. Familial genetic predisposition, epilepsy localization

and antecedent febrile seizures. Epilepsy Res 2007; 73:104-10.

Harries R. Iron deficiency anaemia: does it really matter?

Occasional Review, paediatrics and child health 2007; 17(4)143.

Jones T, Jacobsen SJ, Childhood febrile seizure: overview and

implication. Int J Med Sci 2007; 4:110-114.

Akbar MA, Roya N, Babak K.Evaluation of iron status in 9

months to 5 years old children with febrile seizure. Iran J Child

Neurology 2010; 4:45-50.

J Ayub Med Coll Abbottabad 2012;24(3-4)

http://www.ayubmed.edu.pk/JAMC/24-3/Nadia.pdf

Abdur Rehman KN, Al Trushi AM. The association between iron

deficiency anaemia and febrile seizure. Duhok Med J 2010; 4:60-66.

Pisacane A, Sansone R, Impagliazzo N, Coppola A, Ronaldo P,

D'Apuzzo A, Tregrossi C. Iron deficiency anaemia and febrile

convulsions: case-control study in children under 2 years. MBJ

; 313(7153):343.

Daoud AS, Batieha A, Abu-Ekteish F, Gharaibh N, Ajlouni S,

Hijazi S. Iron status: a possible risk factor for the first febrile

seizure. Epilepsia 2002; 34(7):740-3.

Kobrinsky NI, Yager JY, Cheang Ms, Yatscoff RW, Tenenbein

M. Does iron deficiency raise the seizure threshold? J child

Neurol 1995; 10(2):105-9.

Naveed-ur-Rehman, Billoo AG. Association between iron

deficiency anaemia and febrile seizures. J cool Physicians Surg

Pak 2008 Jun; 15(6):338-40.

Bidabadi E, Mashouf M. Association between iron deficiency

anaemia and first febrile convulsion. A case-control study.

Seizure 2009; 18(5):347-51.

Abaskhanian A, Vahid Shahi K, Parvinnejad N. The Association

between iron deficiency and the first episode of febrile seizure. J

Babol Univ Med Sci 2009; 11(3):32-36.

Asadi-Pooya AA, Ghetmiri E. Red blood cell indices in children

with idiopathic epilepsy: A case-control study, Clinical

Neurology and Neurosurgery 2006;108(6):614-15.

Vaswani M, Dharaskar P G, Kulkarni S, Ghosh K. Iron

Deficiency as a Risk Factor for First Febrile Seizure. Indian

paediatrics j 2009; 3:1-3.

Susan A, Zarrrin Taj KD, Mustafa A, Amin S, Zohreh K, Shahla

A, et al. Relationship Between Iron Deficiency anaemia and

febrile seizures. Iran J Child Neurology 2010; 4:27-30.

Hartfield DS, Tan J, Yager JY, Rosychuk RJ, Spady D, Haines C,

Craig WR. The association between iron deficiency and febrile

seizures in childhood. Clin Pediatr (Phila). 2009; 48:420-6.

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Published

2012-12-01

How to Cite

Waheed, N., & Butt, M. A. (2012). IRON STATUS: IS THERE A ROLE IN FEBRILE SEIZURES?. Journal of Ayub Medical College Abbottabad, 24(3-4), 128–130. Retrieved from https://demo.ayubmed.edu.pk/jamc/index.php/jamc/article/view/2049

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