ASSOCIATION OF MATERNAL HYPERTENSION WITH PLACENTAL ABRUPTION
Abstract
Background: Placental abruption is one of the leading causes of maternal mortality and morbidity.Many causes predispose an expecting mother to placental abruption, such as trauma, previous
history, smoking, ethnicity and hypertension. The present study concentrated on maternal
hypertension as a cause of abruption. Methods: All subjects of this comparative study underwent a
complete obstetrical clinical workup comprising history, general physical examination, abdominal
and pelvic examination, and relevant investigations. The maternal condition was assessed and
managed according to established labour ward protocols, which included both pharmacological and
surgical intervention. Patients were allotted various subgroups for detailed data analysis and
comparative analysis. Results: A total of 50 cases and 50 controls for placental abruption were
studied during the study period. Both groups were compared based on parity, gestational age,
proteinurea, haemoglobin, and hypertension. Mean systolic blood pressure (SBP) of cases in this
study was 155±7.8 mmHg versus mean SBP for controls was 120±14 mmHg. Mean diastolic blood
pressure (DBP) of the cases was 104±6.6 mmHg compared to controls where mean DBP was 71±11
mmHg. Among the controls, 45 (90%) had blood pressures in the normal range. There was
statistically significant differences between cases and controls with respect to hypertension (p<0.01).
Conclusion: Placental abruption is strongly associated with maternal hypertension.
Keywords: Placental Abruption, Hypertension, Maternal Morbidity, Antepartum Haemorrhage (APH)
References
Ananth CV, Getahun D, Peltier MR, Smulian JC. Placental
abruption in term and preterm gestations: evidence for
heterogeneity in clinical pathways. Obstet Gynecol
;107:785-92.
Ananth CV, Savitz DA, Bowes WA, Jr., Luther ER. Influence of
hypertensive disorders and cigarette smoking on placental
abruption and uterine bleeding during pregnancy. Br J Obstet
Gynaecol 1997;104:572-8.
Ananth CV, Savitz DA, Williams MA. Placental abruption and
its association with hypertension and prolonged rupture of
membranes: a methodologic review and meta-analysis. Obstet
Gynecol 1996 ;88:309-18.
Cnattingius, S. Maternal age modifies the effect of maternal
smoking on intrauterine growth retardation but not on late fetal
death and placental abruption. Am J Epidemiol 1997;145:319-
Hibbard BM, Hibbard ED. Aetiological Factors in Abruptio
Placentae. Br Med J 1963;2(5370):1430-6.
Tasleem H, Tasleem S, Adil MM, siddique M, Waheed K. Corelation of pregnancy induced hypertension with placental
abruption and effect of antihypertensive therapy. Rawal Med J
;30:59-61.
Kramer MS, Usher RH, Pollack R, Boyd M, Usher S. Etiologic
determinants of abruptio placentae. Obstet Gynecol
;89:221-6.
Rasmussen S, Irgens LM, Bergsjo P, Dalaker K. The occurrence
of placental abruption in Norway 1967-91. Acta Obstet Gynecol
Scand 1996;75:222-8.
Sheiner E, Shoham-Vardi I, Hadar A, Hallak M, Hackmon R,
Mazor M. Incidence, obstetric risk factors and pregnancy
outcome of preterm placental abruption: a retrospective analysis.
J Matern Fetal Neonatal Med 2002;11(1):34-9.
Williams MA, Lieberman E, Mittendorf R, Monson RR,
Schoenbaum SC. Risk factors for abruptio placentae. Am J
Epidemiol 1991;134:965-72.
Pritchard JA, Mason R, Corley M, Pritchard S. Genesis of severe
placental abruption. Am J Obstet Gynecol 1970;108(1):22-7.
Ananth CV, Oyelese Y, Yeo L, Pradhan A, Vintzileos AM.
Placental abruption in the United States, 1979 through 2001:
temporal trends and potential determinants. Am J Obstet Gynecol
;192:191-8.
Oyelese Y, Ananth CV. Placental abruption. Obstet Gynecol
;108:1005-16.
Mackenzie AP, Schatz F, Krikun G, Funai EF, Kadner S,
Lockwood CJ. Mechanisms of abruption-induced premature
rupture of the fetal membranes: Thrombin enhanced decidual
matrix metalloproteinase-3 (stromelysin-1) expression. Am J
Obstet Gynecol 2004;191:1996-2001.
Liquat NF, Shoaib T, Shuja S. A study of abruptio placentae. J
Surg Pak 2006;11(1):27-30.
Downloads
Published
How to Cite
Issue
Section
License
Journal of Ayub Medical College, Abbottabad is an OPEN ACCESS JOURNAL which means that all content is FREELY available without charge to all users whether registered with the journal or not. The work published by J Ayub Med Coll Abbottabad is licensed and distributed under the creative commons License CC BY ND Attribution-NoDerivs. Material printed in this journal is OPEN to access, and are FREE for use in academic and research work with proper citation. J Ayub Med Coll Abbottabad accepts only original material for publication with the understanding that except for abstracts, no part of the data has been published or will be submitted for publication elsewhere before appearing in J Ayub Med Coll Abbottabad. The Editorial Board of J Ayub Med Coll Abbottabad makes every effort to ensure the accuracy and authenticity of material printed in J Ayub Med Coll Abbottabad. However, conclusions and statements expressed are views of the authors and do not reflect the opinion/policy of J Ayub Med Coll Abbottabad or the Editorial Board.
USERS are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author. This is in accordance with the BOAI definition of open access.
AUTHORS retain the rights of free downloading/unlimited e-print of full text and sharing/disseminating the article without any restriction, by any means including twitter, scholarly collaboration networks such as ResearchGate, Academia.eu, and social media sites such as Twitter, LinkedIn, Google Scholar and any other professional or academic networking site.