IN VITRO RESPONSE OF TRACHEAL SMOOTH MUSCLE FROM HYPERRESPONSIVE GUINEA PIGS TO CELIPROLOL

Authors

  • Asma Shaukat
  • Sumera Kazmi
  • Robina Shaheen

Abstract

Background: The use of β-blockers is limited by adverse effects such as bronchospasm in asthmatics.
Third generation β-blockers such as celiprolol may show better respiratory tolerability because they
lack β-blocker induced broncho-constriction. Method: Effect of celiprolol on the histamine induced
contraction of tracheal muscle strips prepared from ovalbumin-sensitised guinea pigs was studied.
Using oxygenated Krebs-Henseleit solution as the nutrient medium, the trachealis muscle activity was
measured with isometric force displacement transducer and recorded on 4-channel Oscillograph.
Result: Celiprolol 10-4 M shifted the concentration-response curve of histamine downwards and to the
right. Mean of amplitude of contraction, percent responses and deviations when compared with the
control group were significantly different (p<0.05). Conclusion: Celiprolol antagonised histamineinduced contractions of tracheal muscle of guinea pigs. So it may be considered safe in patients with
asthma. However, further clinical evaluation and exploratory work is required.
Keywords: Celiprolol, Histamine, Chronic Obstructive Airway Disease (COAD), Tracheal muscle

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Published

2012-12-01

How to Cite

Shaukat, A., Kazmi, S., & Shaheen, R. (2012). IN VITRO RESPONSE OF TRACHEAL SMOOTH MUSCLE FROM HYPERRESPONSIVE GUINEA PIGS TO CELIPROLOL. Journal of Ayub Medical College Abbottabad, 24(3-4), 85–86. Retrieved from https://demo.ayubmed.edu.pk/jamc/index.php/jamc/article/view/1937

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