MALIGNANT PHYLLODES TUMOUR OF THE BREAST
Abstract
Background: Malignant Phyllodes Tumour (MPT) is considered to be a rare disease of the breast. Themost frequent clinical presentation of a MPT is a rapidly growing breast lump. Methods: Consecutive
cases of MPT registered between Jan 1, 1995 and Dec 31, 2012 at the Shaukat Khanum Memorial
Cancer Hospital and Research Centre, Lahore, Pakistan, were reviewed, to obtain information on age,
tumour size, treatment given, disease-free survival, and overall survival. Disease-free survival was
computed between the dates of surgery and recurrence, whereas, the overall survival time between the
dates of diagnosis and last contact, both in months. Results: A total of 101 cases of Phyllodes tumour
were recorded. These included: malignant tumours (42) benign (27), and borderline (32). Malignant
Phyllodes tumours (42 cases) were studied further and 41 included for additional analysis. The mean
age of the women in the study was 40.3±12.5 (22-72 years). Of the 33 patients who were disease-free
after surgery, 15 had a recurrence, whereas, 18 did not have a recurrence. In those who had surgery
alone versus those who received radiation treatment in addition to surgery, the median disease-free
survival was 117 and 44.2 months, respectively. The mean overall survival time was 33.7 months.
Conclusion: In this study, patients presented at a younger age than in other studies. Further exploration
into molecular, biologic, geographic, and socioeconomic factors is needed to clearly understand the
epidemiology of this disease in our population.
Keywords: Phyllodes tumour, age, recurrence, breast cancer, women, Pakistan
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