FETO-MATERNAL OUTCOMES OF MATERNAL SEPSIS: A SNAPSHOT OF THE ILLNESS

Authors

  • Humaira Jadoon Gynae Deptt. Ayub TMedical College Abbottabad
  • Iram Sarwar Gynae Deptt. Ayub TMedical College Abbottabad
  • Anisa Fawad Gynae Deptt. Ayub TMedical College Abbottabad
  • Salma Rehman Gynae Deptt. Ayub TMedical College Abbottabad
  • Shehla Noor Gynae Deptt. Ayub TMedical College Abbottabad
  • Maryam Bibi Gynae Deptt. Ayub TMedical College Abbottabad

DOI:

https://doi.org/10.55519/JAMC-03-12121

Keywords:

Maternal Sepsis, Septic Shock, PROM, LBW, Intra-uterine death, Placenta previa

Abstract

Abstract: Background: Maternal sepsis is a life-threatening condition with serious adverse feto-maternal outcomes. This descriptive cross-sectional study aimed to study the incidence of common feto-maternal outcomes of maternal sepsis in our hospital. Methods: Pregnant females with singleton pregnancy as per inclusion/exclusion criteria were enrolled in the study. A detailed medical history was taken and physical and obstetrical examination was done. They were investigated for the cause of their febrile illness and managed as per department protocols. Data was recorded in a pre-designed pro forma. Results: The most common cause of infection was UTI (32; 42.6%) followed by genital infections (20; 26.7%) and respiratory tract infections (15; 20%). In 8 (10.7%) patients, the cause couldn’t be found. Only one patient developed sepsis and was admitted to the medical ICU. That pregnancy resulted in PROM and an infant with low birth weight was delivered. Both the mother and the child survived and were discharged from the hospital. There was no mortality in our study group. Conclusion: Though sepsis was associated with adverse feto-maternal outcomes in our study, the study design prevents us from drawing any conclusions from this study concerning maternal sepsis in our region. Further research is needed to determine the true magnitude of the problem.

References

Singer M, Deutschman CS, Seymour CW, et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016;315(8):801–810.

World Health Organization. (2020). Trends in maternal mortality 2000 to 2017: estimates by WHO, UNICEF, UNFPA, World Bank Group and the United Nations Population Division. Geneva: WHO.

UNICEF (2021). Maternal sepsis in South Asia: A regional review. Kathmandu: UNICEF Regional Office for South Asia.

Bonet M, Souza JP, Abalos E, et al. The Global Maternal Sepsis Study and Awareness Campaign (GLOSS): study protocol. Reprod Health. 2020;17(1):10.

Aktepe OH, Çırakoğlu A, Dünder İ. A New Marker for Predicting Adverse Outcome in Sepsis in Obstetrics: Sepsis in Obstetrics Score. J Matern Fetal Neonatal Med. 2017;30(19):2322-2326.

Stephens AJ, Chauhan SP, Barton JR, Sibai BM. Maternal Sepsis: A Review of National and International Guidelines. Am J Perinatol. 2023;40(7):718-730.

Naz R, Bashir F, Ullah Z, Manzoor N, Nisar S, Manzoor N. Prediction of ICU Admission and its Outcome a Prospective Study of Different Scoring Systems in Women with Pregnancy Associated Sepsis. Pakistan J Med Health Sci. 2022;16(12):607-.

Pérez LAR, Cruz LAR, Vega MDV, Cruz AER, Cruz AER. Treatment of Sepsis in pregnancy, Childbirth and the Puerperium: Update According to New Evidence. ESPOCH Congresses: The Ecuador J STEAM. 2021:1734–44-–44.

Soomro P, Bhatti N, Abid K. Fetomaternal Outcomes among Pregnant Females Suffering from Malaria, A Study from Interior Sindh, Pakistan. Pakistan J Med Res. 2021;60(3):111-6.

Lee SWH, Gottlieb SL, Chaiyakunapruk N. Healthcare resource utilisation pattern and costs associated with herpes simplex virus diagnosis and management: a systematic review. BMJ open. 2022;12(1):e049618.

Barton M, Forrester AM, McDonald J. Update on congenital cytomegalovirus infection: Prenatal prevention, newborn diagnosis, and management. Paediatrics & Child Health. 2020;25(6):395-.

Begum A, Jabeen A, Lakho R, Zaheen Z, Bala M, Bhutto A. Prevalence of Urinary Tract Infection during Pregnancy at Tertiary Care Hospital: A Cross-Sectional Study. Pakistan Journal of Medical & Health Sciences. 2022 Jul 2;16(05):851-.

Qazi T, Ainuddin J. Prevalence and Causative Organisms of Asymptomatic Bacteriuria among Pregnant Women in Karachi, Pakistan. J Coll Comm Phys Sri Lanka. 2021;27(2).

Madinger NE, Greenspoon JS, Ellrodt AG. Pneumonia during pregnancy: has modern technology improved maternal and fetal outcome? Am J Obstet Gynecol. 1989;161(3):657-62.

Munn MB, Groome LJ, Atterbury JL, Baker SL, Hoff C. Pneumonia as a complication of pregnancy. J Matern Fetal Med. 1999;8(4):151-4.

Jin Y, Carriere KC, Marrie TJ, Predy G, Johnson DH. The effects of community-acquired pneumonia during pregnancy ending with a live birth. Am J Obstet Gynecol. 2003;188(3):800-6.

Jenkins TM, Troiano NH, Graves CR, Baird SM, Boehm FH. Mechanical ventilation in an obstetric population: characteristics and delivery rates. Am J Obstet Gynecol. 2003;188(2):549-52.

Richey SD, Roberts SW, Ramin KD, Ramin SM, Cunningham FG. Pneumonia complicating pregnancy. Obstet Gynecol. 1994;84(4):525-8.

Panting-Kemp A, Geller SE, Nguyen T, Simonson L, Nuwayhid B, Castro L. Maternal deaths in an urban perinatal network, 1992-1998. Am J Obstet Gynecol. 2000;183(5):1207-12.

Goldenberg RL, Hauth JC, Andrews WW. Intrauterine infection and preterm delivery. New England journal of medicine. 2000;342(20):1500-7.

Han YW, Shen T, Chung P, Buhimschi IA, Buhimschi CS. Uncultivated bacteria as etiologic agents of intra-amniotic inflammation leading to preterm birth. Journal of clinical microbiology. 2009;47(1):38-47.

Combs CA, Gravett M, Garite TJ, Hickok DE, Lapidus J, Porreco R, Rael J, Grove T, Morgan TK, Clewell W, Miller H. Amniotic fluid infection, inflammation, and colonization in preterm labor with intact membranes. American journal of obstetrics and gynecology. 2014;210(2):125-e1.

Additional Files

Published

2023-07-09

Issue

Vol. 35 No. 3 (2023): JOURNAL OF AYUB MEDICAL COLLEGE ABBOTTABAD

Section

ORIGINAL ARTICLE

License

Copyright (c) 2023 Humaira Jadoon, Iram Sarwar, Anisa Fawad, Salma Rehman, Shehla Noor, Maryam Bibi

Creative Commons License

This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License.

Journal of Ayub Medical College, Abbottabad is an OPEN ACCESS JOURNAL which means that all content is FREELY available without charge to all users whether registered with the journal or not. The work published by J Ayub Med Coll Abbottabad is licensed and distributed under the creative commons License  CC BY ND Attribution-NoDerivs. Material printed in this journal is OPEN to access, and are FREE for use in academic and research work with proper citation. J Ayub Med Coll Abbottabad accepts only original material for publication with the understanding that except for abstracts, no part of the data has been published or will be submitted for publication elsewhere before appearing in J Ayub Med Coll Abbottabad. The Editorial Board of J Ayub Med Coll Abbottabad makes every effort to ensure the accuracy and authenticity of material printed in J Ayub Med Coll Abbottabad. However, conclusions and statements expressed are views of the authors and do not reflect the opinion/policy of J Ayub Med Coll Abbottabad or the Editorial Board.

USERS are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author. This is in accordance with the BOAI definition of open access.

AUTHORS retain the rights of free downloading/unlimited e-print of full text and sharing/disseminating the article without any restriction, by any means including twitter, scholarly collaboration networks such as ResearchGate, Academia.eu, and social media sites such as Twitter, LinkedIn, Google Scholar and any other professional or academic networking site.

Most read articles by the same author(s)