THE ROLE OF LYMPH NODE METASTASIS IN EARLY GASTRITIS INDIVIDUALS FOLLOWING NONCURATIVE ENDOSCOPIC RESECTION: A SYSTEMATIC REVIEW AND META-ANALYSIS

Authors

  • Masoumeh Rostami
  • Mazin Hadi Kzar
  • Zahraa Hamzaa Abd alzahraa
  • Ali Abdul Kadhim Ruhaima
  • Sarah A. Hamood
  • Alzahraa S. Abdulwahid
  • Sarmad Dheyaa Noori
  • Ahmed Hussien Alawadi
  • Ali Alsaalamy
  • Ban Saifuddin Mahmoud

DOI:

https://doi.org/10.55519/JAMC-04-12050

Keywords:

Noncurative endoscopic resection, Early gastric cancer, Endoscopic dissection

Abstract

Background: Recent studies suggest that individuals who underwent noncurative endoscopic resection for gastric cancer may require additional surgery. We conducted a comprehensive systematic review and meta-analysis to investigate the risk of lymph node metastasis in these cases. Methods: We comprehensively examined relevant literature by extensively reviewing electronic databases such as PubMed, Cochrane Library, and Google Scholar. Subsequently, we analyzed clinicopathological outcomes and calculated pooled odds ratios and 95 percent confidence intervals using diverse effects models. Results: This analysis included 12 papers with 4808 individuals who underwent additional surgery after noncurative endoscopic resection for early gastric cancer. The results indicated significant associations between lymph node metastasis and submucosal invasion (Odd ratio 2.04, 95% (CI): 1.58–2.63, I 2 = 88.7%; p<0.001), vertical margin (Odd ratio 6.11, 95% (CI): 1.94–19.23, I 2 = 0%; p<0.001), lymphatic invasion (Odd ratio 10.02, 95% (CI): 7.57–13.27, I 2 = 92%; p<0.000), and vascular invasion (Odd ratio 7.11, 95% (CI): 5.49–9.22, I 2=92%; p<0.000). Conclusion: When choosing factors for surgical treatment, it is essential to thoroughly consider the invasion of lymph nodes, vascular system, submucosa, and positive vertical margin.

Author Biographies

Masoumeh Rostami

1-Department of Immunotherapy and Leishmania Vaccine Research, Pasteur Institute of Iran, Tehran-Iran. 2-Cellular and Molecular Research Center, Tajan Institute of Higher Education, Ghaemshahr-Iran

Mazin Hadi Kzar

College of Physical Education and Sport Sciences, Al-Mustaqbal University, 51001 Hillah, Babil-Iraq

Zahraa Hamzaa Abd alzahraa

College of Pharmacy, National University of Science and Technology, Dhi Qar-Iraq

Ali Abdul Kadhim Ruhaima

Department of Medical Engineering, AL-Nisour University College, Baghdad-Iraq

Sarah A. Hamood

Department of Medical Engineering, Al-Esraa University College, Baghdad-Iraq

Alzahraa S. Abdulwahid

Department of Medical Laboratories Technology, Al-Hadi University College, Baghdad-Iraq

Sarmad Dheyaa Noori

Pharmaceutical Chemistry Department, College of Pharmacy, Al-Ayen University, Thi-Qar-Iraq

Ahmed Hussien Alawadi

1-College of Technical Engineering, the Islamic University, Najaf-Iraq 2-College of Technical Engineering, the Islamic University of Al Diwaniyah-Iraq 3-College of Technical Engineering, the Islamic University of Babylon-Iraq

Ali Alsaalamy

College of Technical Engineering, Imam Ja’afar Al‐Sadiq University, Al‐Muthanna-Iraq

Ban Saifuddin Mahmoud

Law Department, University of Babylon, Hillah, Babil-Iraq

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Additional Files

Published

2023-10-12

Issue

Vol. 35 No. 4 (2023): JOURNAL OF AYUB MEDICAL COLLEGE ABBOTTABAD

Section

SYSTEMATIC REVIEW

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Copyright (c) 2023 Masoumeh Rostami

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