A BIZARRE PROGRESSION OF CHRONIC LYMPHOCYTIC LEUKAEMIA INTO DIFFUSE LARGE B-CELL LYMPHOMA

Authors

  • Danish Shakeel Department of Clinical Haematology, Dow University of Health Sciences, Karachi
  • Hira Qadir Department of Clinical Haematology, Dow University of Health Sciences, Karachi
  • Mahad Mirza Baig Dow University of Health Sciences, Karachi
  • Shah Mureed Ojla Dow University of Health Sciences, Karachi

DOI:

https://doi.org/10.55519/JAMC-03-11640

Abstract

A 65-year-old male presented with complaints of weakness, lethargy, abdominal pain, and low-grade fever for the last few months. His examination revealed generalized lymphadenopathy and splenomegaly. A subsequent laboratory workup revealed atypical lymphoid cells with prominent double-bright positivity of CD19 and CD5 markers. Further investigations revealed deletion of the ATM (11q22.3) gene, and in accordance with other diagnostic factors, the patient was diagnosed with B-cell chronic lymphocytic leukaemia. Thus, treatment was initiated with oral chemotherapy followed by rituximab-bendamustine. After three weeks, he presented to the emergency room with a fever and worsening abdominal pain. On examination, massive splenomegaly was found. After stabilization, a bone marrow biopsy revealed findings which, in light of the clinical symptoms, were consistent with Richter’s transformation of B-Cell chronic lymphocytic leukaemia into Diffuse large B-Cell Lymphoma

References

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Additional Files

Published

2023-07-10

Issue

Vol. 35 No. 3 (2023): JOURNAL OF AYUB MEDICAL COLLEGE ABBOTTABAD

Section

CASE REPORT

License

Copyright (c) 2023 Danish Shakeel , Hira Qadir, Mahad Mirza Baig, Shah Mureed Ojla

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