BENIGN PHYLLODES TUMOUR WITH CYSTIC SQUAMOUS METAPLASIA: A RARE HISTOLOGY FINDING

Authors

  • Shaista Zafar Pakistan Institute of Medical Sciences Islamabad
  • Tagwa Elsheikh Junior Doctor, Sandwell and west Birmingham Hospitals Trust-UK
  • Mirza Sharjil Baig Consultant Histopathologist and HoD for Cellular Pathology Black Country Pathology Services ( Sandwell and west Birmingham Hospitals ) https://orcid.org/0009-0003-0561-9785
  • Javeria Iqbal Consultant Oncoplastic and reconstructive Breast Surgeon, Sandwell and west Birmingham Hospitals Trust. https://orcid.org/0009-0004-1807-8567

DOI:

https://doi.org/10.55519/JAMC-03-11586

Keywords:

Benign Phyllodes Tumour, Borderline Phyllodes ,Cystic Squamous, Metaplasia, Histopathology

Abstract

Phyllodes tumour (PT) comprises 0.3–1% of all breast cancers and 3% of fibroepithelial neoplasm. It occurs more commonly in the fourth and fifth decades of life. Fibroepithelial neoplasms are composed of cells types with two different origins, commonly mesenchymal and epithelial. Histological features are important as this forms the basis of the categorization of PT into benign, borderline and malignant types, thus facilitating management. Metaplasia in any of the two components of PT is rare and the cystic squamous type of metaplasia has even more infrequent histological features. Case: This paper presents the case of a 63-year-old female with a palpable lump in the lower outer quadrant of left breast.  Histology showed a benign Phyllodes tumour with patchy, cystic squamous metaplasia within the lesion, keratin production and foreign-body reaction in response to keratin spillage. The previously done core biopsy was also reviewed, which showed focal stromal cell condensation and features overlapping between benign and borderline phyllodes tumours. Conclusion: The case was presented because of its unique and rare histological picture of Cystic squamous metaplasia in benign PT and a further rarer finding of foreign body reaction to keratin spillage.

Author Biography

Javeria Iqbal, Consultant Oncoplastic and reconstructive Breast Surgeon, Sandwell and west Birmingham Hospitals Trust.

   

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Additional Files

Published

2023-07-12

Issue

Vol. 35 No. 3 (2023): JOURNAL OF AYUB MEDICAL COLLEGE ABBOTTABAD

Section

CASE REPORT

License

Copyright (c) 2023 Shaista Zafar, Tagwa Elsheikh, Mirza Sharjil Baig, Javeria Iqbal

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