NON-SURGICAL TREATMENT PROGNOSIS FOR LARYNGEAL CANCER BASED ON AMERICAN JOINT COMMITTEE ON CANCER STAGING AND T AND N INTEGER SCORE

Authors

  • Mohammad Hasan Larizadeh Clinical Research Development Unit, Shafa Hospital, Kerman University of Medical Sciences, Kerman
  • Ahmad Naghibzadeh-Tahami Social Determinants of Health Research Center, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman
  • Hadi Eslami Department of Otolaryngology, Head and Neck Surgery, Kerman University of Medical Sciences, Kerman https://orcid.org/0000-0002-8480-5177

DOI:

https://doi.org/10.55519/JAMC-03-11523

Abstract

Background: The American Joint Committee on Cancer (AJCC) system is the most acceptable staging method. In this study, an attempt has been made to evaluate the survival rate of laryngeal cancer based on the AJCC and T and N integer scores (TANIS). Methods: In this prospective cohort study, from March 2004 to March 2021, laryngeal cancer patients who were considered for non-surgical treatment were included.معیارهای خروج: متاستاز، عدم تحمل پروتکل مطالعه، درمان ناقص به هر دلیل یا جراحی قبلی ضایعه Exclusion criteria were: metastasis, intolerance to the study protocol, incomplete treatment for any reason, or previous surgery on the lesion. معیارهای خروج عبارت بودند از: متاستاز، عدم تحمل پروتکل مطالعه، درمان ناقص به هر دلیل یا جراحی قبلی روی ضایعه. «نتایج کامل» بار نشد امتحان مجدد درحال تلاش مجدد… درحال تلاش مجدد…  Radiation alone was considered for T1-T2 lesions without nodal involvement. Sequential or concomitant chemoradiation (based on physician choice) was considered for locoregionally advanced patients (T3/T4 or node positive). The 2-year, 5-year and 10-year overall survival (OS) and progression-free survival (PFS) rates were estimated using Kaplan-Meier method. Cox -Regression method was used for covariates analysis. Results: The 2-year, 5-year and 10-year overall survival (OS) rates in all patients were estimated to be 82%, 70% and 41%, respectively. The 2-year, 5-year and 10-year progression-free survival (PFS) rates in all patients were estimated to be 78%, 59% and 41%, respectively. The 5-year OS rates for stages I, II, III, IVa, and IVb were 83, 84, 51, 12, and 19 percent, respectively. The 5-year OS rates for TANIS 1, 2, and 3 were 85, 62 and 53 percent, respectively. Based on multivariate analysis, the group stage (p=0.001), TANIS group (p=0.003) and tumour subsite. (p=0.006) were independently effective in survival rates. Conclusion: TANIS-3 can simply predict prognosis of non- surgically treated laryngeal cancers. The separation of different prognostic groups by TANIS is better than the AJCC system. More extensive studies are necessary to confirm this.

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Additional Files

Published

2023-07-09

Issue

Vol. 35 No. 3 (2023): JOURNAL OF AYUB MEDICAL COLLEGE ABBOTTABAD

Section

ORIGINAL ARTICLE

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Copyright (c) 2023 Mohammad Hasan Larizadeh, Ali Naghibzadeh, Hadi Eslami

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