A COMPARISON OF SKELETAL AGE OF THALASSAEMIC PATIENTS OF 9–15 YEARS WITH CHRONOLOGICAL AGE BY RADIOGRAPHY
Abstract
Background: Thalassemia is inherited disorder characterized by haemolytic anaemia, due to complete absence or reduced β-globin chain synthesis, stimulating pathological bone marrow overstimulation and altered erythropoiesis. The change in bone mass ultimately results into miss interpretation of bone age once assed from x-ray radiograph. The aims compare skeletal age of thalassaemic children of 9–15 years with chronological age by x-ray wrist bones. Methods: This was cross sectional analytical study; the study was conducted in conjunction with Fatimid Hospital Peshawar Pakistan and Out Patients Department (OPD) of paediatrics for minor illness (other than Thalassemia) Khyber Teaching Hospital August 2014 to January 2015. A total 156 samples were selected convenient sampling to make comparison of bone age and chronological age between thalassaemic children (age 9–15years) and age sex matched normal control. A structure data collection check list was used to collect data X-ray findings (bone age). SPSS 20 was used for statistical analysis. Results: The results showed a total of 156 children with their mean age 11.9±2.2, male were 97 (62.2%) and females 59 (37.8%). Out of thalassaemic (n=76) majority 49 (62.8%) were male as compared to female 29 (37.2%). The mean chorological age among both of group were not significantly different (p=0.67). However, the bone age was significantly different from each other (p=0001). Pearson’s correlation analysis revealed that was strong correlation between erupt teeth and bone age (r=0.462, p=0.0001). Conclusions: Skeletal age assessment was found to be suboptimal along with chronological age in children and adolescents suffering from thalassemia. Keywords: Chronological age; B-Thalassemia Major; Bone age; Paediatrics; Sex matchedReferences
National Health Portal of India. Thalassemia. [Internet]. [cited 2017 April 9]. Available from: https://www.nhp.gov.in/Thalassemia
Arjmand Rafsanjani Kh, Razzaghy-Azhar M, Zahedi-Schoolami L, Vossough P, Modarres A, Modarres A, et al. Bone mineral density in beta-thalasemia major and intermedia, correlation with biochemical and hormonal profiles. Iran J Blood Cancer 2009;1(4):121–7.
Moayeri H, Oloomi Z. Prevalence of growth and puberty failure with respect to growth hormone and gonadotropins secretion in beta-thalassemia major. Arch Iran Med 2006;9(4):329–34.
Zhang SY, Liu G, Liu LJ, Ma ZG, Han YS, Shen XZ, et al. Relationship of certain skeletal maturity indicators of hand and wrist with adolescent growth spurt. Zhonghua Yi Xue Za Zhi 2008;88(31):2198–200.
Luke LS, Reisbick MH. Polycarbonate crowns. In: Stewart RE, Barber TK, Troutman KC, Wei SH, editors. Pediatric dentistry scientific foundation and clinical practice. 1st ed. St Louis, Pa: CV Mosby Co, 1982; p.894–8.
Fishman LS. Radiographic evaluation of skeletal maturation. A clinically oriented method based on hand wrist films. Angle Orthod 1982;52(2):88–112.
Negi KS. Reliability of MP3 (middle phalanx of 3rd finger) Stages in Assessment of Skeletal Maturation –A Correlative Study. Orthod Dentofac Orthop J 2009;1–12.
Warhekar AM, Wanjari PV, Phulambrikar T. Correlation of radiographic and chronological age in human by using Demjan’s method: Aradiographic study. J Indian Acad Oral Med Radio 2014;23(1):1–4.
Toth ZO, Udvar O, Angyal J. Chronological age estimation based on dental panoramic radiography. Fogorv Sz 2014;107(3):93–8.
Manzoor Mughal A, Hassan N, Ahmed A. The applicability of the Greulich & Pyle Atlas for bone age assessment in primary school-going children of Karachi, Pakistan. Pak J Med Sci 2014;30(2):409–11.
Malina RM. Skeletal age and age verification in youth sport. Sports Med 2011;41(11):925–47.
Hattab FN. Patterns of physical growth and dental development in Jordanian children and adolescents with thalassemia major. J Oral Sci 2013;55(1):71–7.
Chatterjee R, Bajoria R. Critical appraisal of growth retardation and pubertal disturbances in thalassemia. Ann N Y Acad Sci 2010;1202:100–14.
Jimenez-Castellanos J, Carmona A, Catalina-Herrera CJ, Vinuales M. Skeletal maturation of wrist and hand ossification centers in normal Spanish boys and girls: a study using the Greulich-Pyle method. Acta Anat (Basel) 1996;155(3):206–11.
Benigno V, Bertelloni S, Baroncelli GI, Bertacca L, Di Peri S, Cuccia L, et al. Effects of thalassemia major on bone mineral density in late adolescence. J Pediatr Endocrinol Metab 2003;16(Suppl 2):337–42.
Saka N, Sukur M, Bundak R, Anak S, Neyzi O, Gedikoglu G. Growth and puberty in thalassemia major. J Pediatr Endocrinol Metab 1995;8(3):181–6.
Shalitin S, Carmi D, Weintrob N, Phillip M, Miskin H, Kornreich L, et al. Serum ferritin level as a predictor of impaired growth and puberty in thalassemia major patients. Eur J Haematol 2005;74(2):93–100.
Downloads
Published
Issue
Section
License
Journal of Ayub Medical College, Abbottabad is an OPEN ACCESS JOURNAL which means that all content is FREELY available without charge to all users whether registered with the journal or not. The work published by J Ayub Med Coll Abbottabad is licensed and distributed under the creative commons License CC BY ND Attribution-NoDerivs. Material printed in this journal is OPEN to access, and are FREE for use in academic and research work with proper citation. J Ayub Med Coll Abbottabad accepts only original material for publication with the understanding that except for abstracts, no part of the data has been published or will be submitted for publication elsewhere before appearing in J Ayub Med Coll Abbottabad. The Editorial Board of J Ayub Med Coll Abbottabad makes every effort to ensure the accuracy and authenticity of material printed in J Ayub Med Coll Abbottabad. However, conclusions and statements expressed are views of the authors and do not reflect the opinion/policy of J Ayub Med Coll Abbottabad or the Editorial Board.
USERS are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author. This is in accordance with the BOAI definition of open access.
AUTHORS retain the rights of free downloading/unlimited e-print of full text and sharing/disseminating the article without any restriction, by any means including twitter, scholarly collaboration networks such as ResearchGate, Academia.eu, and social media sites such as Twitter, LinkedIn, Google Scholar and any other professional or academic networking site.
